Portal de Periódicos da CAPES

Collagen Injection for Intrinsic Sphincteric Deficiency in Men

1996; Lippincott Williams & Wilkins; Volume: 155; Issue: 1 Linguagem: Inglês

10.1016/s0022-5347(01)66525-x

1527-3792

Sherif R. Aboseif, Helen E. O’Connell, Akihiro Usui, Edward J. McGuire,

Reconstructive Surgery and Microvascular Techniques

No AccessJournal of UrologyClinical Urology: Original Article1 Jan 1996Collagen Injection for Intrinsic Sphincteric Deficiency in Men Sherif R. Aboseif, Helen E. O'Connell, Akihiro Usui, and Edward J. McGuire Sherif R. AboseifSherif R. Aboseif , Helen E. O'ConnellHelen E. O'Connell , Akihiro UsuiAkihiro Usui , and Edward J. McGuireEdward J. McGuire View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)66525-XAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We evaluated the efficacy of collagen injections in the treatment of male urinary incontinence due to intrinsic sphincteric deficiency. Materials and Methods: A total of 88 men (mean age 68 years) with mild to severe intrinsic sphincter deficiency underwent a mean of 3.5 transurethral injections of collagen (mean total volume injected 25 ml.). Patients were subdivided into 2 groups based on use of more than 3 or 3 or fewer pads per day. Patient age, pad use before treatment, duration of leakage, number of injections, volume of collagen used and etiology of incontinence were compared for the 2 groups. Results: Of the patients 42 became nearly completely dry, 19 had substantial improvement but still required 1 to 3 pads per day, 14 consistently used fewer pads but still more than 3 per day and 13 showed no improvement. Most injections were performed with the patient under local anesthesia and no significant morbidity occurred. Conclusions: In select patients collagen injections appear to be effective, easy to deliver and safe. Pretreatment incontinence severity, concomitant detrusor abnormalities and etiology of intrinsic sphincteric deficiency other than radical retropubic prostatectomy were associated with a worse response to collagen therapy. References 1 : The injection treatment of stress incontinence. Brit. J. Obst. Gynaec.1938; 45: 67. Google Scholar 2 : Deux incontinences apres adenonectomic queries par injection de paraffine dans de perinee. Acta Urol. Belg.1955; 23: 259. Google Scholar 3 : Treatment of urinary incontinence with sclerosing solutions. Indications, results, complications. Urol. Int.1963; 15: 225. Google Scholar 4 : Polytef augmentation urethroplasty. Correction of surgically incurable urinary incontinence by injection technique. Arch. Surg.1973; 107: 379. Google Scholar 5 : Periurethral Teflon injection for urinary incontinence. J. Urol.1974; 111: 180. Link, Google Scholar 6 : Migration and granulomatous reaction after periurethral injection of polytef (Teflon). J.A.M.A.1984; 251: 3277. Crossref, Medline, Google Scholar 7 : Histologic studies on the fate of soluble collagen injected into canine vocal folds. Laryngoscope1986; 96: 1248. Google Scholar 8 : Collagen implants in the human larynx. Pathological examinations of two cases. Arch. Otorhinolaryngol.1988; 245: 203. Google Scholar 9 : Treatment of urinary incontinence by the periurethral implantation of glutaraldehyde cross-linked collagen. J. Urol.1989; 141: 538. Link, Google Scholar 10 : Fascial slings and bladder neck tapering in the treatment of male neurogenic incontinence. J. Urol.1992; 147: 1073. Link, Google Scholar 11 : Upper urinary tract deterioration after implantation of artificial urinary sphincter. Scand. J. Urol. Nephrol.1990; 24: 31. Google Scholar 12 : Assessment of urethral sphincter function after prostatectomy. Adv. Urol.1995; 8: 195. Google Scholar 13 : The use of injectable collagen to correct velopharyngeal insufficiency. Laryngoscope1990; 100: 269. Google Scholar 14 : Gax-collagen injection to correct an enlarged tracheoesophageal fistula for vocal prosthesis. Laryngoscope1988; 98: 1350. Google Scholar 15 : Gax-collagen injection to correct aspiration problems after subtotal laryngectomy. Laryngoscope1990; 100: 663. Google Scholar 16 : Treatment of urethral incontinence by collagen injection--one year follow up. J. Urol., part 21990; 143: 224A. abstract 142. Google Scholar 17 : Collagen injection therapy for urinary incontinence. Urol. Clin. N. Amer.1994; 21: 177. Crossref, Medline, Google Scholar 18 : Long-term followup of intraurethral collagen for female stress incontinence. J. Urol., part 21995; 153: 433A. abstract 818. Google Scholar 19 : Postprostatectomy incontinence: pathophysiology, evaluation, and management. Urol. Clin. N. Amer.1991; 18: 229. Google Scholar 20 : Urodynamics in radical retropubic prostatectomy. Scand. J. Urol. Nephrol.1989; 23: 21. Google Scholar 21 : Urodynamic evaluation of incontinence in patients undergoing modified Campbell radical retropubic prostatectomy: a prospective study. J. Urol.1984; 132: 708. Link, Google Scholar Departments of Urology, University of Texas Medical School, Houston, Texas, and University of California School of Medicine, San Francisco, California.© 1996 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byWESTNEY O, BEVAN-THOMAS R, PALMER J, CESPEDES R and McGUIRE E (2018) TRANSURETHRAL COLLAGEN INJECTIONS FOR MALE INTRINSIC SPHINCTER DEFICIENCY: THE UNIVERSITY OF TEXAS-HOUSTON EXPERIENCEJournal of Urology, VOL. 174, NO. 3, (994-997), Online publication date: 1-Sep-2005.DIKRANIAN A, CHANG J, RHEE E and ABOSEIF S (2018) THE MALE PERINEAL SLING: COMPARISON OF SLING MATERIALSJournal of Urology, VOL. 172, NO. 2, (608-610), Online publication date: 1-Aug-2004.MADJAR S, JACOBY K, GIBERTI C, WALD M, HALACHMI S, ISSAQ E, MOSKOVITZ B, BEYAR M and NATIV O (2018) BONE ANCHORED SLING FOR THE TREATMENT OF POST-PROSTATECTOMY INCONTINENCEJournal of Urology, VOL. 165, NO. 1, (72-76), Online publication date: 1-Jan-2001.GOMES C, BRODERICK G, SÁNCHEZ-ORTIZ R, PREATE D, ROVNER E and WEIN A (2018) ARTIFICIAL URINARY SPHINCTER FOR POST-PROSTATECTOMY INCONTINENCE: IMPACT OF PRIOR COLLAGEN INJECTION ON COST AND CLINICAL OUTCOMEJournal of Urology, VOL. 163, NO. 1, (87-90), Online publication date: 1-Jan-2000.CLEMENS J, BUSHMAN W and SCHAEFFER A (2018) QUESTIONNAIRE BASED RESULTS OF THE BULBOURETHRAL SLING PROCEDUREJournal of Urology, VOL. 162, NO. 6, (1972-1976), Online publication date: 1-Dec-1999.SMITH D, APPELL R, RACKLEY R and WINTERS J (2018) COLLAGEN INJECTION THERAPY FOR POST-PROSTATECTOMY INCONTINENCEJournal of Urology, VOL. 160, NO. 2, (364-367), Online publication date: 1-Aug-1998.SCHAEFFER A, CLEMENS J, FERRARI M and STAMEY T (2018) THE MALE BULBOURETHRAL SLING PROCEDURE FOR POST-RADICAL PROSTATECTOMY INCONTINENCEJournal of Urology, VOL. 159, NO. 5, (1510-1515), Online publication date: 1-May-1998.ELSERGANY R and GHONIEM G (2018) COLLAGEN INJECTION FOR INTRINSIC SPHINCTERIC DEFICIENCY IN MEN: A REASONABLE OPTION IN SELECTED PATIENTSJournal of Urology, VOL. 159, NO. 5, (1504-1506), Online publication date: 1-May-1998.STOTHERS L, GOLDENBERG S and LEONE E (2018) COMPLICATIONS OF PERIURETHRAL COLLAGEN INJECTION FOR STRESS URINARY INCONTINENCEJournal of Urology, VOL. 159, NO. 3, (806-807), Online publication date: 1-Mar-1998.SMITH J, SWIERZEWSKI S, BIHRLE W, MALONE M and LIBERTINO J (2018) ENDOSCOPIC INJECTION OF GLUTARALDEHYDE CROSS-LINKED COLLAGEN FOR EFFERENT LIMB INCOMPETENCE IN THE INDIANA RESERVOIRJournal of Urology, VOL. 159, NO. 3, (804-805), Online publication date: 1-Mar-1998.Sanchez-Ortiz R, Broderick G, Chaikin D, Malkowicz S, Van Arsdalen K, Blander D and Wein A (2018) COLLAGEN INJECTION THERAPY FOR POST-RADICAL RETROPUBIC PROSTATECTOMY INCONTINENCE: ROLE OF VALSALVA LEAK POINT PRESSUREJournal of Urology, VOL. 158, NO. 6, (2132-2136), Online publication date: 1-Dec-1997.Martins F, Bennett C, Dunn M, Filho D, Keller T and Lieskovsky G (2018) ADVERSE PROGNOSTIC FEATURES OF COLLAGEN INJECTION THERAPY FOR URINARY INCONTINENCE FOLLOWING RADICAL RETROPUBIC PROSTATECTOMYJournal of Urology, VOL. 158, NO. 5, (1745-1749), Online publication date: 1-Nov-1997.Berman C and Kreder K (2018) Comparative Cost Analysis of Collagen Injection and Fascia Lata Sling Cystourethropexy for the Treatment of Type III Incontinence in WomenJournal of Urology, VOL. 157, NO. 1, (122-124), Online publication date: 1-Jan-1997.Elsharaby M, Abo-Farha O, Rasheed M, Omar A, Elgamasy A and Ghoniem G (2018) A New Technique for Treatment of Simple Post-Prostatectomy Urinary Incontinence: Preliminary ExperienceJournal of Urology, VOL. 156, NO. 6, (1972-1974), Online publication date: 1-Dec-1996.Klutke C, Nadler R, Tiemann D and Andriole G (2018) Early Results with Antegrade Collagen Injection for Post-Radical Prostatectomy Stress Urinary IncontinenceJournal of Urology, VOL. 156, NO. 5, (1703-1706), Online publication date: 1-Nov-1996.Herschorn S, Steele D and Radomski S (2018) Followup of Intraurethral Collagen for Female Stress Urinary IncontinenceJournal of Urology, VOL. 156, NO. 4, (1305-1309), Online publication date: 1-Oct-1996. Volume 155Issue 1January 1996Page: 10-13 Advertisement Copyright & Permissions© 1996 by American Urological Association, Inc.MetricsAuthor Information Sherif R. Aboseif More articles by this author Helen E. O'Connell More articles by this author Akihiro Usui More articles by this author Edward J. McGuire More articles by this author Expand All Advertisement PDF downloadLoading ...