Transport of ionic species through skin
1988; Elsevier BV; Volume: 28-30; Linguagem: Inglês
10.1016/0167-2738(88)90460-2
ISSN1872-7689
AutoresJ.B. Phipps, Rama Padmanabhan, G.A. Lattin,
Tópico(s)Lipid Membrane Structure and Behavior
ResumoThe literature pertaining to the transdermal iontophoretic delivery of drugs spans over eighty years. The general definition of iontophoresis is the introduction of ionic species into the body via an applied electric potential for therapeutic purposes. In this review, the structure of the skin is described and evidence that ions migrate along shunt pathways, such as hair follicles and sweat glands, is cited. Finally, experimental data comparing the efficiency of drug delivery through excised pig, rabbit, and human skin for ionic lithium, sodium, magnesium, calcium, potassium, salicylate, pyridostigmine, and propranolol are summarized. The efficiency of drug delivery was found to decrease with increasing molecular weight and to be substantially lower for divalent cations than for monovalent cations of similar molecular weight.
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