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Sterols from the Caribbean sponge Neofibularia nolitangere. Isolation of two novel polyhydroxysteroids

1995; Elsevier BV; Volume: 60; Issue: 11 Linguagem: Inglês

10.1016/0039-128x(95)00117-9

1878-5867

Valeria Costantino, Ernesto Fattorusso, A Mangoni, Maurizio Pansini,

Traditional and Medicinal Uses of Annonaceae

The sterol composition of the Caribbean sponge Neofibularia nolitangere has been investigated. In addition to usual sterols this sponge elaborates comparable amounts of 24-methylene-4 alpha-methyl-5 alpha-cholest-8-en-3 beta-ol (1), which is very unusual among sponge sterols, and lesser quantities of two new polyoxygenated sterols, (24S)-24-ethyl-5 alpha-cholest-8-ene-5,6 beta,7 alpha-triol (2) and (24S)-24-ethyl-5 alpha-cholest-8(14)-ene-5,6 beta,7 alpha-triol (3).