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A model for intramolecular recombination of herpesvirus DNA leading to the formation of circular, circular-linear and fragmented genomes

1978; Elsevier BV; Volume: 75; Issue: 3 Linguagem: Inglês

10.1016/0022-5193(78)90339-9

1095-8541

Yechiel Becker,

Viral-associated cancers and disorders

Abstract A model is presented for intramolecular recombination of herpesvirus DNA. It is proposed that the terminal repeat sequences of the viral DNA contain insertion sequences which may integrate with homologous repeat sequences between the long ( L ) and short ( S ) components. In class 2 herpes-virus DNA (as defined by Honess & Watson, 1977) in which the repeat sequences flank the S component only, circular-linear DNA molecules can be formed as an intermediate step. Reorientation of the S component leads to the formation of two DNA isomers. In class 3 herpesvirus DNA in which repeat sequences flank both the L and S components, either circular-linear or 8-shaped DNA molecules are proposed as intermediates leading to the formation of four DNA isomers. Fragmentation of the S component could lead to the formation of small circular DNA molecules.