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Enzyme-alterable alkylating agents.IV. Treatment of cancer in children with repetitive massive doses of S-46, protecting the extremity marrow by tourniquets

1963; Wiley; Volume: 16; Issue: 6 Linguagem: Inglês

10.1002/1097-0142(196306)16

1097-0142

Albert Schilling, Adolph Ulfohn, Olympia Aybar, Stanley J. Miller, Sheldon C. Kravitz, Louis E. Goodman, Samuel E. Gaby, Daniel Bakal, Stanley P. Kramer, Charles E. Williamson, Samuel Sass, Jacob I. Miller, Benjamin Witten, Arnold M. Seligman,

Radiopharmaceutical Chemistry and Applications

CancerVolume 16, Issue 6 p. 727-736 ArticleFree Access Enzyme-alterable alkylating agents. IV. Treatment of cancer in children with repetitive massive doses of S-46, protecting the extremity marrow by tourniquets Albert Schilling M.D., Albert Schilling M.D. Departments of Surgery and Medicine, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md. The Johns Hopkins University School of Medicine, Baltimore, Md. Chemical Research Division, U.S. Army Chemical Research and Development Laboratories, Army Chemical Center, MdSearch for more papers by this authorAdolph Ulfohn M.D., Adolph Ulfohn M.D. Departments of Surgery and Medicine, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md. The Johns Hopkins University School of Medicine, Baltimore, Md. Chemical Research Division, U.S. Army Chemical Research and Development Laboratories, Army Chemical Center, MdSearch for more papers by this authorOlympia Aybar M.D., Olympia Aybar M.D. Departments of Surgery and Medicine, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md. The Johns Hopkins University School of Medicine, Baltimore, Md. Chemical Research Division, U.S. Army Chemical Research and Development Laboratories, Army Chemical Center, MdSearch for more papers by this authorStanley Miller M.D., Stanley Miller M.D. Departments of Surgery and Medicine, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md. The Johns Hopkins University School of Medicine, Baltimore, Md. Chemical Research Division, U.S. Army Chemical Research and Development Laboratories, Army Chemical Center, MdSearch for more papers by this authorSheldon C. Kravitz M.D., Sheldon C. Kravitz M.D. Departments of Surgery and Medicine, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md. The Johns Hopkins University School of Medicine, Baltimore, Md. Chemical Research Division, U.S. Army Chemical Research and Development Laboratories, Army Chemical Center, MdSearch for more papers by this authorLouis E. Goodman M.D., Louis E. Goodman M.D. Departments of Surgery and Medicine, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md. The Johns Hopkins University School of Medicine, Baltimore, Md. Chemical Research Division, U.S. Army Chemical Research and Development Laboratories, Army Chemical Center, MdSearch for more papers by this authorSamuel E. Gaby M.D., Samuel E. Gaby M.D. Departments of Surgery and Medicine, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md. The Johns Hopkins University School of Medicine, Baltimore, Md. Chemical Research Division, U.S. Army Chemical Research and Development Laboratories, Army Chemical Center, MdSearch for more papers by this authorDaniel Bakal M.D., Daniel Bakal M.D. Departments of Surgery and Medicine, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md. The Johns Hopkins University School of Medicine, Baltimore, Md. Chemical Research Division, U.S. Army Chemical Research and Development Laboratories, Army Chemical Center, MdSearch for more papers by this authorStanley P. Kramer PH.D., Stanley P. Kramer PH.D. Departments of Surgery and Medicine, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md. The Johns Hopkins University School of Medicine, Baltimore, Md. Chemical Research Division, U.S. Army Chemical Research and Development Laboratories, Army Chemical Center, MdSearch for more papers by this authorCharles E. Williamson B.S., Charles E. Williamson B.S. Departments of Surgery and Medicine, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md. The Johns Hopkins University School of Medicine, Baltimore, Md. Chemical Research Division, U.S. Army Chemical Research and Development Laboratories, Army Chemical Center, MdSearch for more papers by this authorSamuel Sass B.S., Samuel Sass B.S. Departments of Surgery and Medicine, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md. The Johns Hopkins University School of Medicine, Baltimore, Md. Chemical Research Division, U.S. Army Chemical Research and Development Laboratories, Army Chemical Center, MdSearch for more papers by this authorJacob I. Miller B.S., Jacob I. Miller B.S. Departments of Surgery and Medicine, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md. The Johns Hopkins University School of Medicine, Baltimore, Md. Chemical Research Division, U.S. Army Chemical Research and Development Laboratories, Army Chemical Center, MdSearch for more papers by this authorBenjamin Witten PH.D., Benjamin Witten PH.D. Departments of Surgery and Medicine, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md. The Johns Hopkins University School of Medicine, Baltimore, Md. Chemical Research Division, U.S. Army Chemical Research and Development Laboratories, Army Chemical Center, MdSearch for more papers by this authorArnold M. Seligman M.D., Arnold M. Seligman M.D. Departments of Surgery and Medicine, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md. The Johns Hopkins University School of Medicine, Baltimore, Md. Chemical Research Division, U.S. Army Chemical Research and Development Laboratories, Army Chemical Center, MdSearch for more papers by this author Albert Schilling M.D., Albert Schilling M.D. Departments of Surgery and Medicine, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md. The Johns Hopkins University School of Medicine, Baltimore, Md. Chemical Research Division, U.S. Army Chemical Research and Development Laboratories, Army Chemical Center, MdSearch for more papers by this authorAdolph Ulfohn M.D., Adolph Ulfohn M.D. Departments of Surgery and Medicine, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md. The Johns Hopkins University School of Medicine, Baltimore, Md. Chemical Research Division, U.S. Army Chemical Research and Development Laboratories, Army Chemical Center, MdSearch for more papers by this authorOlympia Aybar M.D., Olympia Aybar M.D. Departments of Surgery and Medicine, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md. The Johns Hopkins University School of Medicine, Baltimore, Md. Chemical Research Division, U.S. Army Chemical Research and Development Laboratories, Army Chemical Center, MdSearch for more papers by this authorStanley Miller M.D., Stanley Miller M.D. Departments of Surgery and Medicine, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md. The Johns Hopkins University School of Medicine, Baltimore, Md. Chemical Research Division, U.S. Army Chemical Research and Development Laboratories, Army Chemical Center, MdSearch for more papers by this authorSheldon C. Kravitz M.D., Sheldon C. Kravitz M.D. Departments of Surgery and Medicine, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md. The Johns Hopkins University School of Medicine, Baltimore, Md. Chemical Research Division, U.S. Army Chemical Research and Development Laboratories, Army Chemical Center, MdSearch for more papers by this authorLouis E. Goodman M.D., Louis E. Goodman M.D. Departments of Surgery and Medicine, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md. The Johns Hopkins University School of Medicine, Baltimore, Md. Chemical Research Division, U.S. Army Chemical Research and Development Laboratories, Army Chemical Center, MdSearch for more papers by this authorSamuel E. Gaby M.D., Samuel E. Gaby M.D. Departments of Surgery and Medicine, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md. The Johns Hopkins University School of Medicine, Baltimore, Md. Chemical Research Division, U.S. Army Chemical Research and Development Laboratories, Army Chemical Center, MdSearch for more papers by this authorDaniel Bakal M.D., Daniel Bakal M.D. Departments of Surgery and Medicine, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md. The Johns Hopkins University School of Medicine, Baltimore, Md. Chemical Research Division, U.S. Army Chemical Research and Development Laboratories, Army Chemical Center, MdSearch for more papers by this authorStanley P. Kramer PH.D., Stanley P. Kramer PH.D. Departments of Surgery and Medicine, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md. The Johns Hopkins University School of Medicine, Baltimore, Md. Chemical Research Division, U.S. Army Chemical Research and Development Laboratories, Army Chemical Center, MdSearch for more papers by this authorCharles E. Williamson B.S., Charles E. Williamson B.S. Departments of Surgery and Medicine, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md. The Johns Hopkins University School of Medicine, Baltimore, Md. Chemical Research Division, U.S. Army Chemical Research and Development Laboratories, Army Chemical Center, MdSearch for more papers by this authorSamuel Sass B.S., Samuel Sass B.S. Departments of Surgery and Medicine, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md. The Johns Hopkins University School of Medicine, Baltimore, Md. Chemical Research Division, U.S. Army Chemical Research and Development Laboratories, Army Chemical Center, MdSearch for more papers by this authorJacob I. Miller B.S., Jacob I. Miller B.S. Departments of Surgery and Medicine, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md. The Johns Hopkins University School of Medicine, Baltimore, Md. Chemical Research Division, U.S. Army Chemical Research and Development Laboratories, Army Chemical Center, MdSearch for more papers by this authorBenjamin Witten PH.D., Benjamin Witten PH.D. Departments of Surgery and Medicine, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md. The Johns Hopkins University School of Medicine, Baltimore, Md. Chemical Research Division, U.S. Army Chemical Research and Development Laboratories, Army Chemical Center, MdSearch for more papers by this authorArnold M. Seligman M.D., Arnold M. Seligman M.D. Departments of Surgery and Medicine, Sinai Hospital of Baltimore, Inc., Belvedere Ave. at Greenspring, Baltimore 15, Md. The Johns Hopkins University School of Medicine, Baltimore, Md. Chemical Research Division, U.S. Army Chemical Research and Development Laboratories, Army Chemical Center, MdSearch for more papers by this author First published: June 1963 https://doi.org/10.1002/1097-0142(196306)16:6 3.0.CO;2-2Citations: 5AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL References 1 Bierman, H. R.; Kelly, K. H.; Marshall, G. J.; and Byron, R. L., Jr.: Protective effect of leukapheresis in man against large dose antineoplastic chemotherapy. Blood 17: 303– 313, 1961. 2 Conrad, M. E., Jr., and Crosby, W. H.: Massive nitrogen mustard therapy in Hodgkin's disease with protection of bone marrow by tourniquets. Blood 16: 1089– 1103, 1960. 3 Creech, O., Jr., Krementz, E. T.; Ryan, R. F.; and Winblad, J. N.: Chemotherapy of cancer; regional perfusion utilizing extracorporeal circuit. Ann. Surg. 148: 616– 632, 1958. 4 Crosby, W. H.: Personal communication. 5 Custer, R. P.; and Ahlfeldt, F. E.: Studies on structure and function of bone marrow; II, variations in cellularity in various bones with advancing years of life and their relative response to stimuli. J. Lab. & Clin. Med. 17: 960– 962, 1932. 6 Goodman, L. E.; Kramer, S. P.; Gaby, S. D.; Bakal, D.; Solomon, R. D.; Williamson, C. E.; Miller, J. I.; Sass, S.; Witten, B.; and Seligman, A. M.: Enzyme-alterable alkylating agents; II, clinical evaluation of N,N'-bis[(2-chloroethylthio)-acetyl]-1,2-ethylenediamine (S-46). Cancer 15: 1056– 1061, 1962. 7 Goodman, L. E.; Schilling, A.; Kramer, S. P.; Ulfohn, A.; Miller, S.; Kravitz, S.; Gaby, S. D.; Bakal, D.; Witten, B.; and Seligman, A. M.: Effective use of new alkylating agent in doses lethal to bone marrow with protection by tourniquets of marrow in extremities. S. Forum 12: 130132, 1961. 8 Karnofsky, D. A.; Graef, I.; and Smith, H. W.: Studies on mechanism of action of nitrogen and sulfur mustards in vivo. Am. J. Path. 24: 275– 291, 1948. 9 Lawrence, W., Jr., Kuehn, P.; Masle, E. T.; and Miller, D. G.: Abdominal tourniquet for regional chemotherapy. J. Surg. Res. 1: 142– 151, 1961. 10 McFarland, W.; Granville, N. B.; and Dameshek, W.: Autologous bone marrow infusion as adjunct in therapy of malignant disease. Blood 14: 503– 521, 1959. 11 Miller, D. G.: Personal communication. 12 Owens, A. H., Jr.: Personal communication. 13 Schilling, A.; Goodman, L. E.; Kramer, S. P.; Ulfohn, A.; Miller, S.; Kravitz, S.; Gaby, S. D.; Bakal, D.; Williamson, C.; Sass, S.; Miller, J. I.; Witten, B.; and Seligman, A. M.: Tourniquet protection of extremity marrow in administering large doses of N,N'-ethylene bis (2-chloroethylthioacetamide) (S-46). Proc. Am. A. Cancer Res. 3: 265, 1961. 14 Schilling, A.; Goodman, L. E.; Ulfohn, A.; Gaby, S. D.; Bakal, D.; Aybar, O.; Kramer, S. P.; Williamson, C. E.; Sass, S.; Miller, J. I.; Witten, B.; and Seligman, A. M.: Repetitive massive chemotherapy with sulfur mustard analogs and bone marrow protection by vascular occlusion. In Cancer Chemotherapy Reports, No. 16. Bethesda, Md. Cancer Chemotherapy National Service Center. 1962; pp. 527– 530. 15 Seligman, A. M.; Schilling, A.; Goodman, L. E.; Kramer, S. P.; Miller, S.; Kravitz, S.; Ulfohn, A.; Gaby, S. D.; Bakal, D.; Aybar, O.; Williamson, C. E.; Sass, S.; Miller, J. I.; and Witten, B.: Effective use of new alkylating agent in children with protection by tourniquet of marrow in extremities. Sinai Hosp. J. 10: 91– 94, 1961. 16 Seligman, A. M.; Ulfohn, A.; Gaby, S. D.; Goodman, L. E.; Aybar, O.; Kramer, S. P.; Bakal, D.; Haber, S.; Williamson, C. E.; Miller, J. I.; Sass, S.; and Witten, B.: Enzyme alterable alkylating agents; new approach to regional chemotherapy by intra-arterial infusion of new short-lived alkylating agents. Ann. Surg. 156: 429– 441, 1962. 17 Witten, B.; Williamson, C. E.; Miller, J. I.; Sass, S.; Kramer, S. P.; Goodman, I. E.; Ulfohn, A.; and Seligman, A. M.: New short half-life alkylating agents for intra-arterial regional chemotherapy. In Cancer Chemotherapy Reports, No. 16. Bethesda, Md. Cancer Chemotherapy National Service Center. 1962; pp. 515– 516. 18 Witten, B.; Williamson, C. E.; Sass, S.; Miller, J. I.; Best, R.; Wicks, G. E., Jr., Kramer, S. P.; Weinberg, T.; Solomon, R. D.; Goodman, I. E., and Seligman, A. M.: Enzyme-alterable alkylating agents; I, synthesis, chemical properties, and toxicities of sulfur mustards containing enzyme-susceptible amide bonds. Cancer 15: 1041– 1055, 1962. Citing Literature Volume16, Issue6June 1963Pages 727-736 ReferencesRelatedInformation