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Mechanisms of depression: the role of neurogenesis

2004; Elsevier BV; Volume: 1; Issue: 4 Linguagem: Inglês

10.1016/j.ddmec.2004.10.007

1740-6765

Fritz A. Henn, Barbara Vollmayr, Alexander Sartorius,

Nerve injury and regeneration

The behavioral changes in depression can relate to alterations in hippocampal function. A variety of inputs to the hippocampus can effect mood, including norepinephrine (NE), serotonin (5HT) and cortisol, all factors activated by stress. These are thought to act through activation of CREB and neurotrophins such as BDNF. Stress has been shown to decrease hippocampal neurogenesis and most antidepressants increase neurogenesis, leading to the hypothesis that changes in the rate of new neuron formation might underlie depressive illnesses.