Imaging entire genetically functional DNA molecules with the scanning tunneling microscope
1993; American Institute of Physics; Volume: 11; Issue: 4 Linguagem: Inglês
10.1116/1.578310
ISSN1520-8559
AutoresDavid P. Allison, Thomas Thundat, K. Bruce Jacobson, Lawrence A. Bottomley, R. J. Warmack,
Tópico(s)Surface and Thin Film Phenomena
ResumoDeoxyribonucleic acid (DNA) can be immobilized on epitaxial gold surfaces treated with 2-dimethylaminoethanethiol preventing removal of the molecules due to forces exerted by the scanning tunneling microscope probe tip. We present reproducible images of entire plasmid molecules on these surfaces and discuss differences in image contrast that we have observed.
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