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Combining Radiation and Immunotherapy: A New Systemic Therapy for Solid Tumors?

2014; American Association for Cancer Research; Volume: 2; Issue: 9 Linguagem: Inglês

10.1158/2326-6066.cir-14-0069

2326-6074

Chad Tang, Xiaohong Wang, Hendrick Soh, Steven N. Seyedin, María Angélica Cortez, Sunil Krishnan, Erminia Massarelli, David S. Hong, Aung Naing, Adi Diab, Daniel R. Gomez, Huiping Ye, John V. Heymach, Ristuko Komaki, James P. Allison, Padmanee Sharma, James W. Welsh,

Cancer, Stress, Anesthesia, and Immune Response

Abstract With the recent success of checkpoint inhibitors and other immunomodulating agents, there has been renewed interest in the combination of such agents with radiation. The biologic premise behind such a strategy is that the tumor-antigen release achieved by localized radiation will promote specific tumor targeting by the adaptive immune system, which can be augmented further by systemic immune-stimulating agents. In this manner, clinicians hope to induce a phenomenon known as the abscopal effect, whereby localized radiation results in immune-mediated tumor regression in disease sites well outside of the radiation field. Herein, we present a comprehensive overview of the early clinical and preclinical evidence behind this approach. Cancer Immunol Res; 2(9); 831–8. ©2014 AACR.