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Structural Basis for ON-and OFF-Center Responses in Retinal Ganglion Cells

1976; American Association for the Advancement of Science; Volume: 194; Issue: 4261 Linguagem: Inglês

10.1126/science.959847

1095-9203

Edward V. Famiglietti, Helga Kolb,

Neural dynamics and brain function

The inner plexiform layer of the mammalian retina has a bisublaminar organization determined by restricted branching of the terminals of cone bipolar cells and dendrites of class I (large) and class II (small) ganglion cells. Comparison of dendritic field diameters and receptive field center sizes of large ganglion cells suggests that neural circuitry in sublamina a conveys "OFF"-center properties and connections in sublamina b "ON"-center properties to retinal ganglion cells.