Acetyl-l-carnitine enhances acetylcholine release in the striatum and hippocampus of awake freely moving rats
1989; Elsevier BV; Volume: 107; Issue: 1-3 Linguagem: Inglês
10.1016/0304-3940(89)90826-4
ISSN1872-7972
AutoresAssunta Impérato, M. T. Ramacci, Luciano Angelucci,
Tópico(s)Photoreceptor and optogenetics research
ResumoThe effect of acetyl-L-carnitine (ALC) on the spontaneous release of acetylcholine (ACh) in the striatum and hippocampus of freely moving rats was investigated using brain microdialysis coupled with HPLC-electrochemical detection. Systemic administration of ALC, in a dose-dependent manner, stimulated ACh release in both areas, while the D-enantiomer was substantially ineffective. The effect of ALC was strongly Ca2+ dependent and tetrodotoxin (TTX) sensitive. These features of an exocytotic and impulse flow-dependent mechanism suggest that the increase in ACh release is the result of ALC activation of a physiological mechanism in cholinergic neurons.
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