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Light‐Triggered Sequence‐Specific Cargo Release from DNA Block Copolymer–Lipid Vesicles

2012; Wiley; Volume: 52; Issue: 3 Linguagem: Inglês

10.1002/anie.201206783

1521-3773

Alberto Rodríguez‐Pulido, Alina I. Kondrachuk, Deepak K. Prusty, Jia Gao, Maria Antonietta Loi, Andreas Herrmann,

DNA and Nucleic Acid Chemistry

Vesicle buster: Versatile functionalized nanocontainers, based on the stable incorporation of 22 mer DNA-b-PPO block copolymers (DBCs) into lipid vesicles, are presented (see picture). The study shows effective and sequence-specific cargo release from the DBC–lipid vesicles. Hybridization of these vesicles with an oligonucleotide photosensitizer allows for singlet oxygen generation upon irradiation, which induces cargo release.