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ALTERATIONS IN THE NEUROCYTOTOXICITY OF 5,7‐DIHYDROXYTRYPTAMINE BY PHARMACOLOGIC AGENTS IN ADULT AND DEVELOPING RATS*

1978; Wiley; Volume: 305; Issue: 1 Linguagem: Inglês

10.1111/j.1749-6632.1978.tb31519.x

1749-6632

George R. Breese, Robert A. Mueller,

Anesthesia and Sedative Agents

Annals of the New York Academy of SciencesVolume 305, Issue 1 p. 160-174 ALTERATIONS IN THE NEUROCYTOTOXICITY OF 5,7-DIHYDROXYTRYPTAMINE BY PHARMACOLOGIC AGENTS IN ADULT AND DEVELOPING RATS* G. R. Breese, G. R. Breese Department of Psychiatry, Biological Sciences Research Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27514Search for more papers by this authorR. A. Mueller, R. A. Mueller Department of Anesthesiology, Biological Sciences Research Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27514 Department of Pharmacology, Biological Sciences Research Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27514Search for more papers by this author G. R. Breese, G. R. Breese Department of Psychiatry, Biological Sciences Research Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27514Search for more papers by this authorR. A. Mueller, R. A. Mueller Department of Anesthesiology, Biological Sciences Research Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27514 Department of Pharmacology, Biological Sciences Research Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27514Search for more papers by this author First published: June 1978 https://doi.org/10.1111/j.1749-6632.1978.tb31519.xCitations: 32 * Supported by United States Public Health Service Grants HD-03110 and HD-10570. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL References 1 Baumgarten, H. G., A. Björklund, L. Lachenmayer, A. Nobin & U. Stenevi 1971. Long-lasting selective depletion of brain serotonin by 5,6-dihydroxytryptamine. Acta Physiol Scand. Suppl. 373: 1– 15. 2 Breese, G. R. 1975. Chemical and immunochemical lesions by specific neurotoxic substances and antisera. In Handbook of Psychopharmacology. L. L. Iversen, S. D. Iversen & S. H. Snyder, Eds. Vol. 1: 137– 189. Plenum Publishing Corporation. New York , NY . 3 Baumgarten, H. G., A. Björklund, A. F. Holstein & A. Nobin 1972. Chemical degeneration of indoleamine axons in rat brain by 5,6-dihydroxytryptamine; an ultrastructural study. Z. Zellforsch. 129: 256– 271. 4 Breese, G. R., B. R. Cooper, L. D. Grant & R. D. Smith 1974. Biochemical and behavioral alterations following 5,6-dihydroxytryptamine administration into brain. Neuropharmacology 13: 177– 187. 5 Baumgarten, H. G., A. Björklund, L. Lachenmayer & A. Nobin 1973. Evaluation of the effects of 5,7-dihydroxytryptamine on serotonin and catecholamine neurons in the rat CNS. Acta Physiol Scand. Suppl. 391: 1– 19. 6 Baumgarten, H. G., S. J. Victor & W. Lovenberg 1973. Effect of intraventricular injection of 5,7-dihydroxytryptamine on regional tryptophan hydroxylase of rat brain. J. Neurochem. 21: 251– 253. 7 Jacoby, J. G., L. D. Lytle & M. F. Nelson 1974. Long term effects of 5,7-dihydroxytryptamine on brain monoamines. Life Sci. 15: 909– 919. 8 Breese, G. R. & B. R. Cooper 1975. Behavioral and biochemical interactions of 5,7-dihydroxytryptamine with various drugs when administered intracisternally to adult and developing rats. Brain Res. 98: 517– 527. 9 Baumgarten, H. G. & L. Lachenmayer 1972. 5,7-Dihydroxytryptamine: improvement in chemical lesioning of indoleamine neurons in the mammalian brain. Z. Zellforsch. 135: 399– 414. 10 Evetts, K. D. & L. L. Iversen 1970. Effects of protriptyline on the depletion of catecholamines induced by 6-hydroxydopamine in the brain of the rat. J. Pharmacol. 22: 540– 542. 11 Breese, G. R. & T. D. Traylor 1970. Effect of 6-OHDA on brain NE and DA: evidence for selective degeneration of catecholamine neurons. J. Pharmacol. Exp. Ther. 174: 413– 420. 12 Breese, G. R. & T. D. Traylor 1972. Developmental characteristics of brain catecholamines and tyrosine hydroxylase in the rat: effects of 6-OHDA. Brit. J. Pharmacol. 44: 210– 222. 13 Smith, R. D., B. R. Cooper & G. R. Breese 1973. Growth and behavioral changes in developing rats treated intracisternally with 6-hydroxydopamine: evidence for involvement of brain dopamine. J. Pharmacol. Exp. Ther. 185: 609– 619. 14 Cooper, B. R., G. R. Breese, L. D. Grant & J. L. Howard 1973. Effects of 6-hydroxydopamine treatments on active avoidance responding: evidence for involvement of brain dopamine. J. Pharmacol. Exp. Ther. 185: 358– 370. 15 Carlsson, A. 1970. Structural specificity for inhibition of (C14-5HT) uptake by cerebral slices. J. Pharm. Pharmacol. 22: 729– 732. 16 Buczko, W., D. De Gaetiano & S. Garattini 1974. Influence of some tricyclic antidepressant drugs on the uptake of 5-hydroxytryptamine by rat blood platelets. J. Pharm. Pharmacol. 26: 814– 815. 17 Fuller, R. W., K. W. Perry & B. B. Molloy 1974. Effect of an uptake inhibitor on serotonin metabolism in rat brain: studies with 3-(p-trifluoromethylphenoxy) N-methyl-3-phenylpropylamine (Lilly 110140). Life Sci. 15: 1161– 1171. 18 Wong, D. T., J. S. Horng, F. P. Bymaster, K. L. Hauser & B. B. Molloy 1974. A selective inhibitor of serotonin uptake: Lilly 110140, 3-(p-trifluoro-methylphenoxy)-N-methyl-3-phenylpropylamine. Life Sci. 15: 471– 479. 19 Harvey, J. A., S. E. McMaster & L. M. Yunger 1975. p-Chloroamphetamine: selective neurotoxic action in brain. Science 187: 841– 843. 20 Sekerke, H. J., H. E. Smith, J. A. Bushing & E. Sanders-Bush 1975. Correlation between brain levels and biochemical effects of the optical isomers of p-chloroamphetamine. J. Pharmacol. Exp. Ther. 193: 835– 844. 21 Harvey, J. A. & S. E. McMaster 1975. Fenfluramine: evidence for a neurotoxic action on midbrain and a long-term depletion of serotonin. Psychopharmacol. Commun. 1(2): 217– 228. 22 Konkol, R. J., E. Bendeich & G. R. Breese 1977. A morphological and biochemical study of the altered growth pattern of central catecholamine neurons following 6-hydroxydopamine. Brain Res. In press. 23 Kostrzewa, R. M. & J. W. Harper 1975. Comparison of the neonatal effects of 6-hydroxydopa and 6-hydroxydopamine on growth and development of noradrenergic neurons in the central nervous system. In Chemical Tools in Catecholamine Research. G. Jonsson, T. Malmfors & C. Sachs, Eds. Vol. I: 181– 188. North Holland Publishing Company. Amsterdam , The Netherlands . 24 Sachs, C. & G. Jonsson 1975. 5,7-Dihydroxytryptamine induced changes in the postnatal development of central 5-hydroxytryptamine neurons. Med. Biol. 53: 156– 164. 25 Breese, G. R., B. R. Cooper & A. S. Hollister 1975. Involvement of brain monoamines in the stimulant and paradoxical inhibitory effects of methylphenidate. Psychopharmacologia 44: 5– 10. 26 Breese, G. R., B. R. Cooper & R. A. Mueller 1974. Evidence for involvement of 5 hydroxytryptamine in the actions of amphetamine. Brit. J. Pharmacol. 52: 307– 314. 27 Hollister, A. S., G. R. Breese, C. Kuhn, B. R. Cooper & S. M. Schanberg 1976. An inhibitory role for brain 5-HT-containing systems in the locomotor effects of d-amphetamine. J. Pharmacol. Exp. Ther. 198(1): 12– 22. 28 Baumgarten, H. G., S. J. Victor & W. Lovenberg 1975. A developmental study of the effects of 5,7-dihydroxytryptamine on regional tryptophan hydroxylase in rat brain. Psychopharmacol. Commun. 1(1): 75– 88. 29 Lytle, L. D., J. H. Jacoby, M. F. Nelson & H. G. Baumgarten 1974. Longterm effects of 5,7-dihydroxytryptamine administered at birth on the development of brain monoamines. Life Sci. 15: 1203– 1217. 30 Hendley, E. D. & S. H. Snyder 1968. Relationship between the action of monoamine oxidase inhibitors on the noradrenaline uptake system and their antidepressant efficacy. Nature (London) 220: 1330– 1331. 31 Björklund, A., H. G. Baumgarten & A. Nobin 1974. Chemical lesioning of central monoamine axons by means of 5,6-dihydroxytryptamine and 5,7-dihydroxytryptamine. In 5-Hydroxytryptamine and Other Indolealkylamines in Brain. E. Costa, M. Sandler & G. L. Gessa, Eds. Vol. 10: 13– 33. 32 Daly, J., J. Lundstrom & C. R. Creveling 1974. Structure activity correlations in tri-hydroxy-phenethylamines and di-hydroxytryptamine; relationship to cytotoxicity in adrenergic and serotonergic neurons. In Dynamics of Degeneration and Regeneration in Neurons. K. Fuxe, L. Olson & Y. Zotterman, Eds.: 29– 42. Pergamon Press. Oxford , England . 33 Ross, S. B. & A. L. Renyi 1969. Inhibition of the uptake of tritiated-6-hydroxytryptamine in brain tissue. Eur. J. Pharmacol. 7: 270– 277. 34 Fuller, R. W., K. W. Perry & B. B. Molloy 1975. Reversible and irreversible phase of serotonin depletion by 4-chloroamphetamine. Eur. J. Pharmacol. 33: 119– 124. 35 Neckers, L. M., L. Bertilsson, S. H. Koslow & J. L. Meek 1975. Reduction of tryptophan hydroxylase activity and 5-hydroxytryptamine concentration in certain rat brain nuclei after p-chloroamphetamine. J. Pharmacol. Exp. Ther. 196: 333– 338. 36 Baker, P. C., K. M. Hoff & M. D. Smith 1974. The maturation of monoamine oxidase and 5-hydroxyindole acetic acid in regions of the mouse brain. Brain Res. 65: 255– 264. 37 Cohen, G., R. E. Heikkila, B. Allis, F. Cabbat, D. Dembiec, D. MacNamee, C. Mytilineou & B. Winston 1976. Destruction of sympathetic nerve terminals by 6-hydroxydopamine: protection by 1-phenyl-3-(2 thiazolyl)-2-thiourea, diethyldithiocarbamate, methimazole, cysteamine, ethanol and n-butanol. J. Pharmacol. Exp. Ther. 199: 336– 352. 38 Shaywitz, B. A., J. H. Klopper, R. D. Yager & J. W. Gordon 1976. Paradoxical response to amphetamine in developing rats treated with 6-hydroxydopamine. Nature (London) 261: 153– 155. 39 Saller, C. F. & E. M. Stricker 1976. Hyperphagia and increased growth in rats after intraventricular injection of 5,7-dihydroxytryptamine. Science 192: 285– 287. Citing Literature Volume305, Issue1Serotonin NeurotoxinsJune 1978Pages 160-174 ReferencesRelatedInformation