Origin of chi46,XX/46,XY Chimerism in a Human True Hermaphrodite
1980; American Association for the Advancement of Science; Volume: 207; Issue: 4428 Linguagem: Inglês
10.1126/science.7350665
ISSN1095-9203
AutoresGordon W. Dewald, Morey W. Haymond, Jack L. Spurbeck, S. Breanndan Moore,
Tópico(s)Reproductive Biology and Fertility
ResumoUsing chromosome heteromorphisms and blood cell types as genetic markers, we demonstrated chimerism in a chi46,XX/46,XY true hermaphrodite. The pattern of inheritance of the chromosome heteromorphisms indicates that this individual was probably conceived by the fertilization, by two different spermatozoa, of an ovum and the second meiotic division polar body derived from the ovum and subsequent fusion of the two zygotes. This conclusion is based on the identification of the same maternal chromosomes 13, 16, and 21 in both the 46,XX and 46,XY cells of the patient. In the two cell lines of the chimera, chromosomal markers showed different paternal No. 9 chromosomes and sex chromosomes, as well as the same paternal chromosome 22.
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