The CD28-Related Molecule ICOS Is Required for Effective T Cell–Dependent Immune Responses
2000; Cell Press; Volume: 13; Issue: 1 Linguagem: Inglês
10.1016/s1074-7613(00)00011-x
ISSN1097-4180
AutoresAnthony J. Coyle, Sophie M. Lehar, Clare M. Lloyd, Jane Tian, Tracy Delaney, Stephen Manning, Trang Nguyen, Tim Burwell, Helga Schneider, Jose Angel Gonzalo, Michael Gosselin, Laura Rudolph Owen, Christopher E. Rudd, José Carlos Gutierrez‐Ramos,
Tópico(s)Receptor Mechanisms and Signaling
ResumoWhile CD28 is critical for expansion of naive T cells, recent evidence suggests that the activation of effector T cells is largely independent of CD28/B7. We suggest that ICOS, the third member of the CD28/CTLA-4 family, plays an important role in production of IL-2, IL-4, IL-5, and IFNgamma from recently activated T cells and contributes to T cell-dependent B help in vivo. Inhibition of ICOS attenuates lung mucosal inflammation induced by Th2 but not Th1 effector populations. Our data indicate a critical function for the third member of the CD28 family in T cell-dependent immune responses.
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