New unsymmetrical squaraine dyes derived from imidazo[1,5-a]pyridine
2012; Elsevier BV; Volume: 96; Issue: 2 Linguagem: Inglês
10.1016/j.dyepig.2012.10.006
ISSN1873-3743
AutoresYaroslav Prostota, O.D. Kachkovsky, Lucinda V. Reis, Paulo F. Santos,
Tópico(s)Bioactive Compounds and Antitumor Agents
ResumoThe reaction of squaric acid with excess 3-methylimidazo[1,5-a]pyridine afforded almost exclusively the corresponding semisquaraine. The later underwent condensation with several heterocyclic compounds possessing active methyl groups, forming a novel class of unsymmetrical squaraines. The spectral properties of the obtained dyes were investigated and quantum-chemical calculations were performed to examine the dependence of the electronic structure and electron transitions on the molecular constitution of the dyes. The oxygen-generation ability of the new dyes was accessed by the 1,3-diphenylisobenzofuran (DPBF) quenching method, envisioning their potential use as sensitizers for photodynamic therapy (PDT).
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