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Artigo Produção Nacional Revisado por pares
BIBTEX RIS

First report of diffuse cutaneous leishmaniasis and Leishmania amazonensis infection in Rio de Janeiro State, Brazil

2007; Oxford University Press; Volume: 101; Issue: 7 Linguagem: Inglês

10.1016/j.trstmh.2007.01.005

ISSN

1878-3503

Autores

Rilza Beatriz Gayoso de Azeredo-Coutinho, Fátima Conceição‐Silva, A Schubach, Elisa Cupolillo, Leonardo Pereira Quintella, M.F. Madeira, R. S. Pacheco, Cláudia Maria Valete‐Rosalino, Sergio C.F. Mendonça,

Tópico(s)

Trypanosoma species research and implications

Resumo

Diffuse cutaneous leishmaniasis (DCL) is characterised by multiple and progressive cutaneous lesions, resistance to chemotherapy and Leishmania-specific T-cell anergy. We report the first autochthonous DCL case and the first human infection with Leishmania amazonensis in Rio de Janeiro State, Brazil, where only L. braziliensis is considered to be the causative agent of cutaneous leishmaniasis. Leishmania amazonensis was identified by multilocus enzyme electrophoresis and PCR-RFLP. Our case was diagnosed as DCL according to clinical, parasitological, histopathological and immunological criteria. These observations indicate that L. amazonensis is increasing its geographical distribution in Brazil, accounting for unusual clinical presentations in new transmission areas.

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