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Attenuation by acetaminophen of arachidonic acid-induced coronary vasolidation and output of prostaglandins in the isolated rat heart

1981; Elsevier BV; Volume: 72; Issue: 1 Linguagem: Inglês

10.1016/0014-2999(81)90296-x

1879-0712

Joel E. Shaffer, Lauren M. Cagen, Kafait U. Malik,

Nitric Oxide and Endothelin Effects

We studied the effect of acetaminophen on the vascular actions of arachidonic acid and on the output of prostaglandins in the isolated rat heart. Arachidonic acid (33 nmol), administered as a bolus into the heart through the aortic cannula produced vasoconstriction followed by a long lasting vasolidation. Arachidonic acid also markedly increased the output of PGE2 and 6-keto-PGF1α from the heart. In the presence of acetaminophen (0.1–1.0 mM) both the output of prostaglandins and the duration of the coronary vasolidation were attenuated. We suggest that the major component of arachidonic acid-induced coronary vasolidation is mediated through prostaglandin synthesis and is blocked by acetaminophen.