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Intratympanic gentamicin for unilateral Meniere's disease: results of therapy

2003; Wiley; Volume: 28; Issue: 2 Linguagem: Inglês

10.1046/j.1365-2273.2003.00678.x

1365-2273

Ian Bottrill, Andrew D. Wills, Alice Mitchell,

Ear Surgery and Otitis Media

Clinical Otolaryngology & Allied SciencesVolume 28, Issue 2 p. 133-141 Intratympanic gentamicin for unilateral Menière's disease: results of therapy I. Bottrill, I. Bottrill Department of Otolaryngology Radcliffe Infirmary, Oxford, andSearch for more papers by this authorA. D. Wills, A. D. Wills Department of Otolaryngology Radcliffe Infirmary, Oxford, andSearch for more papers by this authorA. L. Mitchell, A. L. Mitchell Addenbrooke's Hospital, Cambridge, UKSearch for more papers by this author I. Bottrill, I. Bottrill Department of Otolaryngology Radcliffe Infirmary, Oxford, andSearch for more papers by this authorA. D. Wills, A. D. Wills Department of Otolaryngology Radcliffe Infirmary, Oxford, andSearch for more papers by this authorA. L. Mitchell, A. L. Mitchell Addenbrooke's Hospital, Cambridge, UKSearch for more papers by this author First published: 04 April 2003 https://doi.org/10.1046/j.1365-2273.2003.00678.xCitations: 9 Mr Ian Bottrill, Consultant ENT Surgeon, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, UK (e-mail: [email protected]). Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Intratympanic gentamicin for unilateral Menière's disease: results of therapy Patients with Menière's disease that remains refractory to conservative treatment have traditionally been subjected to ablative surgery. The purpose of this prospective study was to evaluate the use of intratympanic gentamicin in eliminating incapacitating vertigo, while preserving hearing. Over the past 8 years, 83 patients have received between 1 and 6 intratympanic injections of gentamicin in an out-patient setting, with duration of therapy titrated to individual symptom response and effect on hearing. Using established AAO-HNS guidelines, we present data on 50 patients who have a minimum of 2 years follow-up. Control or significant improvement of definitive Menière's attacks was achieved in 92% of patients and hearing preserved or improved in 76%. Only one patient experienced profound sensorineural hearing loss. 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