Immunosuppressive activity of serum during the development of Experimental Allergic Encephalomyelitis
1974; Elsevier BV; Volume: 11; Issue: 1-3 Linguagem: Inglês
10.1016/0008-8749(74)90001-x
ISSN1090-2163
AutoresArthur A. Vandenbark, Bruce L. Gibbins, David J. Hinrichs,
Tópico(s)RNA Interference and Gene Delivery
ResumoThe development of Experimental Allergic Encephalomyelitis (EAE), an auto-immune disease directed against the central nervous system, causes a marked increase of serum contained alpha globulins. Serum with elevated alpha globulins decreases the uptake of 3H-thymidine into mitogen stimulated normal or immune lymphocytes. The increased alpha globulin levels and immunosuppressive activity parallel the development of clinical signs.
Referência(s)