Artigo Revisado por pares

Amyloid β-protein precursor is associated with extracellular matrix

1990; Elsevier BV; Volume: 515; Issue: 1-2 Linguagem: Inglês

10.1016/0006-8993(90)90619-m

ISSN

1872-6240

Autores

F. George Klier, G. M. Cole, William B. Stallcup, David Schubert,

Tópico(s)

Parkinson's Disease Mechanisms and Treatments

Resumo

The ultrastructural distribution of the amyloid beta-protein precursor (ABPP) in cultures of a neuronal cell line is examined. ABPP is associated with the extensive extracellular matrix (ECM) secreted by these cells. The possible role of matrix associated ABPP in the pathogenesis of Alzheimer's disease is discussed.

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