Amyloid β-protein precursor is associated with extracellular matrix
1990; Elsevier BV; Volume: 515; Issue: 1-2 Linguagem: Inglês
10.1016/0006-8993(90)90619-m
ISSN1872-6240
AutoresF. George Klier, G. M. Cole, William B. Stallcup, David Schubert,
Tópico(s)Parkinson's Disease Mechanisms and Treatments
ResumoThe ultrastructural distribution of the amyloid beta-protein precursor (ABPP) in cultures of a neuronal cell line is examined. ABPP is associated with the extensive extracellular matrix (ECM) secreted by these cells. The possible role of matrix associated ABPP in the pathogenesis of Alzheimer's disease is discussed.
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