Calcitonin gene-related peptide (8–37) does not antagonize calcitonin gene-related peptide in rat spinal cord
1996; Elsevier BV; Volume: 204; Issue: 3 Linguagem: Inglês
10.1016/0304-3940(96)12351-x
ISSN1872-7972
AutoresXiao-Jun Xu, Zsuzsanna Wiesenfeld‐Hallin,
Tópico(s)Anesthesia and Pain Management
ResumoWe have examined the effects of intrathecal (i.t.) human calcitonin gene-related peptide (hCGRP) and its C-terminal fragment hCGRP(8–37), a proposed CGRP antagonist, on the flexor reflex in decerebrate, spinalized, unanesthetized rats. I.t. hCGRP at 26 pmol caused a moderate facilitation of the reflex which was not antagonized by hCGRP(8–37) at doses ranging from 26 pmol to 5.2 nmol. Furthermore, hCGRP(8–37) by itself facilitated the reflex, with no signs of inhibition. It is concluded that the spinal CGRP receptor mediating the spinal facilitatory effect of hCGRP is not antagonized by hCGRP(8–37). Thus, it is unlikely that hCGRP(8–37) can be useful as a spinal analgesic.
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