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Artigo Produção Nacional Revisado por pares
BIBTEX RIS

Spectroscopic, luminescence and in vitro biological studies of solid ketoprofen of heavier trivalent lanthanides and yttrium(III)

2014; Elsevier BV; Volume: 140; Linguagem: Inglês

10.1016/j.jinorgbio.2014.07.008

ISSN

1873-3344

Autores

Diogo A. Gálico, Marcelo G. Lahoud, Marian Rosaly Davolos, Regina C. G. Frem, Thais Fernanda de Campos Fraga‐Silva, James Venturini, Maria Sueli Parreira de Arruda, Gilbert Bannach,

Tópico(s)

Magnetism in coordination complexes

Resumo

Solid-state compounds of the general formulae [ML3] (M = Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu, Y; L = ketoprofen) were synthesized and characterized using infrared, diffuse reflectance and luminescence spectroscopies. IR data suggested that the carboxylate group in ketoprofen is coordinated to the metals as a bidentate ligand. The triplet state energy level was determined using the Gd3 + complex, which exhibited a ketoprofen blue luminescence when excited in the UV region. The compound containing Tb3 + ion was sensitized by the ligand and emitted in the green region of the visible spectrum. On the other hand, for the analogous species containing the dysprosium ion, a competition for luminescence between the Dy3 + and the ligand levels was observed. Finally, Tm3 + complex exhibits only ligand luminescence. These optical behaviors are discussed based on rare earth energy diagrams. In addition, the compounds were evaluated for their anti-inflammatory activities. All the compounds showed a higher production of H2O2 and IL-10 than the ketoprofen, suggesting that the compounds exhibited an immunomodulatory effect and this opens up new perspectives for immunotherapeutic approaches.

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