Fertility in a Man With Cystic Fibrosis
1976; American Medical Association; Volume: 235; Issue: 13 Linguagem: Inglês
10.1001/jama.1976.03260390050033
ISSN1538-3598
Autores Tópico(s)Hemoglobinopathies and Related Disorders
ResumoCYSTIC fibrosis generally has been considered a childhood disease, although many patients now reach adulthood. 1 In addition to other medical problems such as pulmonary and pancreatic insufficiency, male patients are usually infertile because of maldevelopment of mesonephric ducts or mesonephric obstruction and atresia. 2,3 A small number of fertile patients with relatively late-appearing and somewhat milder disease has been identified recently. Feigelson et al 4 and Taussig et al 5 first reported fertility in men with cystic fibrosis, all of whom had late-appearing disease manifestations, particularly pulmonary symptoms. Our patient had well-compensated and late-appearing cystic fibrosis manifested by moderately decreased exercise tolerance and a normal semen analysis, and he had presumably fathered one child. Report of a Case A 30-year-old man was seen for complaints of intermittent diarrhea since 1970 and frequent respiratory infections since1972. Despite severe, productive, early-morning cough since his late teens, he was able to
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