An independent replication of PARK16 in Asian samples
2010; Lippincott Williams & Wilkins; Volume: 75; Issue: 24 Linguagem: Inglês
10.1212/wnl.0b013e318202031f
ISSN1526-632X
AutoresCarles Vilariño‐Güell, Owen A. Ross, Jan Aasly, Linda R. White, Alex Rajput, Ali H. Rajput, Timothy Lynch, Anna Krygowska‐Wajs, Barbara Jasińska‐Myga, Grzegorz Opala, Maria Barcikowska, M.-C. Lee, Fayçal Hentati, Ryan J. Uitti, Zbigniew K. Wszołek, Matthew J. Farrer, Ruey‐Meei Wu,
Tópico(s)Neurological diseases and metabolism
ResumoINFLUENZA VACCINATIONCase reports.Case 1.A previously healthy 38-year-old man presented with acute urinary retention and constipation after 4 days of progressive weakness affecting all 4 limbs and patchy sensory disturbance over the trunk and upper arms.Ten days prior to the onset of symptoms, he had received H1N1 09 influenza (Panvax H1N1, CSL Biotherapies, Parkville, Australia) vaccination and had experienced a spontaneously resolving febrile reaction 24 -48 hours following administration.MRI of the brain, cervical, thoracic, and lumbar spine was performed (figure ,A).Several areas of central cord T2 signal hyperintensity were demonstrated, extending from C3 to C6 and from T7 to L1, and a diagnosis of longitudinally extensive transverse myelitis was made.Serologic investigations for infective and autoimmune etiologies were unremarkable.CSF demonstrated an inflammatory pattern, with 80 ϫ 10 6 /L lymphocytes and 0.78 g/L total protein.The patient received IV methylprednisolone (1 g/d for 3 days), with resolution in power and sphincter function over the following 10 days.Case 2. A previously healthy 19-year-old woman presented with a 7-day history of progressive weakness of all limbs, 21 days after vaccination for H1N1 09 influenza.Symptoms progressed until the patient was unable to walk, and were associated with urinary retention, constipation, and paraesthesia over the trunk and legs.MRI spine demonstrated a transverse myelitis, with high T2 signal and swelling of the cord extending from C2 to C7 and areas of T2 hyperintensity through the proximal thoracic segments (figure ,B).Etiologic investigations were unremarkable, with 10 ϫ 10 6 /L lymphocytes and 0.52 g/L total protein in CSF.IV methylprednisolone was administered for 3 days, with resolution of weakness but persistent paresthesia 3 weeks after treatment.Case 3. A 30-week pregnant 37-year-old woman developed an acute ataxia syndrome 14 days after receipt of the H1N1 09 influenza vaccine.On examination, there was horizontal opsoclonus (ocular flutter) and disrupted smooth pursuit in the
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