The Arabidopsis Circadian Clock Incorporates a cADPR-Based Feedback Loop
2007; American Association for the Advancement of Science; Volume: 318; Issue: 5857 Linguagem: Inglês
10.1126/science.1146757
ISSN1095-9203
AutoresAntony N. Dodd, Michael Gardner, Carlos T. Hotta, Katharine Hubbard, Neil Dalchau, John Love, Jean-Maurice Assie, Fiona C. Robertson, Mia Kyed Jakobsen, Jorge Gonçalves, Dale Sanders, Alex Webb,
Tópico(s)Calcium signaling and nucleotide metabolism
ResumoTranscriptional feedback loops are a feature of circadian clocks in both animals and plants. We show that the plant circadian clock also incorporates the cytosolic signaling molecule cyclic adenosine diphosphate ribose (cADPR). cADPR modulates the circadian oscillator's transcriptional feedback loops and drives circadian oscillations of Ca 2+ release. The effects of antagonists of cADPR signaling, manipulation of cADPR synthesis, and mathematical simulation of the interaction of cADPR with the circadian clock indicate that cADPR forms a feedback loop within the plant circadian clock.
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