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Congestive Heart Failure: Biochemical and Physiological Considerations: Combined Clinical Staff Conference at the National Institutes of Health

1966; American College of Physicians; Volume: 64; Issue: 4 Linguagem: Inglês

10.7326/0003-4819-64-4-904

1539-3704

Eugene Braunwald,

Heart Failure Treatment and Management

Clinical Staff Conference1 April 1966Congestive Heart FailureCombined Clinical Staff Conference at the National Institutes of HealthEUGENE BRAUNWALD, M.D., F.A.C.P., CHARLES A. CHIDSEY, M.D., PETER E. POOL, M.D., EDMUND H. SONNENBLICK, M.D., JOHN ROSS JR., M.D., DEAN T. MASON, M.D., JAMES F. SPANN, M.D., JAMES W. COVELL, M.D.EUGENE BRAUNWALD, M.D., F.A.C.P., CHARLES A. CHIDSEY, M.D., PETER E. POOL, M.D., EDMUND H. SONNENBLICK, M.D., JOHN ROSS JR., M.D., DEAN T. MASON, M.D., JAMES F. SPANN, M.D., JAMES W. COVELL, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-4-904 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDr. Eugene Braun Wald: Congestive heart failure, the subject of today's conference, is the disease state in which an abnormality of myocardial function is responsible for the heart's failure to pump blood at a rate commensurate with the body's requirements. Heart failure occurs so frequently that physicians are, in general, quite familiar with its clinical manifestations and methods of treatment. However, there is lack of agreement concerning the fundamental derangement responsible for this common disease state. Efforts to gain an understanding of the mechanisms responsible for the functional changes occurring in heart failure have constituted one of the objectives of...References1. OLSON RE: Physiology of cardiac muscle, in Handbook of Physiology, Section 2: Circulation Vol. I., edited by HAMILTON, W. F., DOW, P. American Physiological Society. Washington, D. C., 1962, p. 199. Google Scholar2. OLSON RE: Abnormalities of myocardial metabolism. Circ. Res. 15 (supplement 2): 109, 1964. Google Scholar3. BING RJ: Metabolism of the heart. Harvey Lect. 1954-55, Ser. 50: 27, 1956. Google Scholar4. CAINDAVIES DFRE: Breakdown of adenosine triphosphate during a single contraction of working muscle. Biochem. Biophys. Res. Commun. 8: 361, 1962. 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Med. 41: 498, 1965. MedlineGoogle Scholar78. BRAUNWALDROSSFROMMERWILLIAMSSONNENBLICKGAULT EJPLJFEHJH: Clinical observations on paired electrical stimulation of the heart. Amer. J. Med. 37: 700, 1964. CrossrefMedlineGoogle Scholar79. BRAUNWALDSONNENBLICKROSSFROMMER EEHJPL: Editorial—Paired electrical stimulation of the heart: a physiologic riddle and a clinical challenge. Circulation 32: 677, 1965. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: EUGENE BRAUNWALD, M.D., F.A.C.P.; CHARLES A. CHIDSEY, M.D.; PETER E. POOL, M.D.; EDMUND H. SONNENBLICK, M.D.; JOHN ROSSJR., M.D.; DEAN T. MASON, M.D.; JAMES F. SPANN, M.D.; JAMES W. COVELL, M.D.Affiliations: Bethesda, MarylandThis is an edited transcription of a combined clinical staff conference at the Clinical Center, Bethesda, Md., by the National Heart Institute, National Institutes of Health, Public Health Service, U. S. Department of Health, Education, and Welfare.Requests for reprints should be addressed to Eugene Braunwald, M.D., Cardiology Branch, National Heart Institute, Bldg. 10, Room 7-B-15, National Institutes of Health, Bethesda, Md. 20014. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNeurohormonal connections with mitochondria in cardiomyopathy and other diseasesEvaluation of the effects of different treatment modalities on angiogenesis in heart failure patients with preserved ejection fraction via VEGF and sVEGFR-1Substance P Increases Sympathetic Activity During Combined Angiotensin-Converting Enzyme and Dipeptidyl Peptidase-4 InhibitionReply: comments on the interview by William C. 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