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Antibacterial Activities Against Staphylococcus aureus of Terpene Alcohols With Aliphatic Carbon Chains

2010; Taylor & Francis; Volume: 22; Issue: 3 Linguagem: Inglês

10.1080/10412905.2010.9700321

2163-8152

Naoko Togashi, Hajime Hamashima, Akiko Shiraishi, Yoshihiro Inoué, Akihito Takano,

Natural product bioactivities and synthesis

Abstract The antibacterial activities against Staphylococcus aureus of terpene alcohols with aliphatic carbon chains of various lengths were investigated. Farnesol and nerolidol, which each contain two isoprene units, had the strongest antibacterial activities and damaging effects on cell membranes of all the terpene alcohols tested. Plaunotol, which is a diterpene, had antibacterial activity similar to that of sesquiterpenes. The relationship between the length of the carbon chain bonded to the hydroxyl group and activity suggests that the length of the carbon chain is an important determinant of antibacterial activity and cell membrane-damaging activity. It was concluded that the carbon chain length of C10-C12 was appropriate to show the activity. Key Word Index: Terpene alcoholantibacterial activityaliphatic carbon chain Staphylococcus aureus.