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α-(1H-Imidazol-1-yl)alkyl (IMIDA) carboxylic acid esters as prodrugs of carboxylic acid containing drugs

2007; Elsevier BV; Volume: 48; Issue: 26 Linguagem: Inglês

10.1016/j.tetlet.2007.04.121

1873-3581

Susruta Majumdar, Maren Mueller Spaeth, Sashikala Sivendran, Juha Juntunen, Joshua D. Thomas, Kenneth B. Sloan,

Synthesis and biological activity

Abstract Synthesis of α-(1H-imidazol-1-yl)alkyl (IMIDA) carboxylic acid esters have been reported in 2–3 simple steps. α-(1H-Imidazol-1-yl)alkyl (IMIDA) carboxylic acid esters were found to be chemically labile and thus serve as novel prodrugs of carboxylic acids.