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Carbon Coated Zirconium Beads in β-Glucan Gel and Bovine Glutaraldehyde Cross-Linked Collagen Injections for Intrinsic Sphincter Deficiency: Continence and Satisfaction After Extended Followup

2004; Lippincott Williams & Wilkins; Volume: 171; Issue: 3 Linguagem: Inglês

10.1097/01.ju.0000103688.83606.06

1527-3792

Kristin Chrouser, Felecia R. Fick, Apul Goel, Nancy B. Itano, SUSAN D. SWEAT, Deborah J. Lightner,

Reconstructive Surgery and Microvascular Techniques

No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Mar 2004Carbon Coated Zirconium Beads in β-Glucan Gel and Bovine Glutaraldehyde Cross-Linked Collagen Injections for Intrinsic Sphincter Deficiency: Continence and Satisfaction After Extended Followup K.L. CHROUSER, F. FICK, A. GOEL, N.B. ITANO, S.D. SWEAT, and D.J. LIGHTNER K.L. CHROUSERK.L. CHROUSER , F. FICKF. FICK , A. GOELA. GOEL , N.B. ITANON.B. ITANO , S.D. SWEATS.D. SWEAT , and D.J. LIGHTNERD.J. LIGHTNER View All Author Informationhttps://doi.org/10.1097/01.ju.0000103688.83606.06AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: The durability of Durasphere (Carbon Medical Technologies, Saint Paul, Minnesota), used to treat stress urinary incontinence, has not been shown beyond 12 months of followup. Women treated with Durasphere and Contigen (Bard, Inc., Covington, Georgia) at 1 institution between 1996 and 2000 were compared to determine patient satisfaction and urinary continence after extended followup. Materials and Methods: Between April 1996 and September 2000, 56 women were treated with Durasphere at this institution, of whom 43 were available for extended followup. Aged matched patients treated with Contigen were analyzed for comparison. Patient satisfaction and continence at last followup were subjectively assessed via telephone interview. Survival methods (Kaplan-Meier and Cox proportional hazards model) were used to analyze time to failure as a function of treatment group and other potential predictors. Results: Treatment groups (Contigen and Durasphere) were similar with respect to all baseline factors. Treatment was initially effective in 63% of Durasphere and Contigen cases (p = 1.0). At 24 and 36 months Durasphere remained effective in 33% and 21% of patients compared with 19% and 9% for Contigen, respectively. At last followup only 9 patients (21%) treated with Durasphere and 2 (5%) treated with Contigen (median followup 51 and 62 months, respectively) claimed that treatment was still effective. After controlling for differences in followup time there was no significant difference in time to failure between the treatment groups (p = 0.25). A third of patients in each group believed that treatment was a success. Conclusions: Neither Contigen nor Durasphere provides durable improvement in continence. Despite this outcome a third of patients in the 2 groups were satisfied with the treatment outcome. References 1 Appell R.A.: Valsalva leak point pressure (LPP) vs. urethral closing pressure profile (UPP) in the evaluation of intrinsic sphincter deficiency (ISD). 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Link, Google Scholar From the Mayo Clinic, Rochester, Minnesota© 2004 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byGhoniem G, Corcos J, Comiter C, Westney O and Herschorn S (2010) Durability of Urethral Bulking Agent Injection for Female Stress Urinary Incontinence: 2-Year Multicenter Study ResultsJournal of Urology, VOL. 183, NO. 4, (1444-1449), Online publication date: 1-Apr-2010.Lai H, Hsu E, Teh B, Butler E and Boone T (2018) 13 Years of Experience With Artificial Urinary Sphincter Implantation at Baylor College of MedicineJournal of Urology, VOL. 177, NO. 3, (1021-1025), Online publication date: 1-Mar-2007.Lottmann H, Margaryan M, Bernuy M, Grosz A, Aigrain Y, Lortat-Jacob S and Läckgren G (2018) Long-Term Effects of Dextranomer Endoscopic Injections for Treatment of Urinary Incontinence: An Update of a Prospective Study of 31 PatientsJournal of Urology, VOL. 175, NO. 4, (1485-1489), Online publication date: 1-Apr-2006. Volume 171Issue 3March 2004Page: 1152-1155 Advertisement Copyright & Permissions© 2004 by American Urological Association, Inc.Keywordsurethraduraspherebladderglutaraldehyde-cross-linked collagenurinary incontinence, stressMetricsAuthor Information K.L. CHROUSER More articles by this author F. FICK More articles by this author A. GOEL More articles by this author N.B. ITANO More articles by this author S.D. SWEAT More articles by this author D.J. LIGHTNER More articles by this author Expand All Advertisement PDF downloadLoading ...