Effect of chronic ethanol ingestion on mitochondrial permeability and the transport of reducing equivalents
1972; Elsevier BV; Volume: 49; Issue: 3 Linguagem: Inglês
10.1016/0006-291x(72)90460-3
ISSN1090-2104
AutoresArthur I. Cederbaum, Charles S. Lieber, Diana S. Beattie, Emanuel Rubin,
Tópico(s)Biochemical effects in animals
ResumoAbstract Chronic ethanol feeding to rats leads to an increased rate of ethanol metabolism. This increase is not accompanied by altered permeability of the mitochondria to NADH. The activities of the reconstituted malate-aspartate, fatty acid elongation and α-glycerophosphate shuttles for the transport of reducing equivalents into mitochondria were not changed by chronic ethanol ingestion. Thus, in contrast to other reports, these results show that neither increased mitochondrial permeability nor enhanced shuttle activity explains the acceleration of ethanol metabolism produced by chronic ethanol ingestion.
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