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An improved bidentate complex of iridium as a catalyst for hydrogen isotope exchange

2005; Wiley; Volume: 48; Issue: 4 Linguagem: Inglês

10.1002/jlcr.921

1099-1344

John M. Herbert, Andrew D. Kohler, Alan H. McNeill,

Boron Compounds in Chemistry

Journal of Labelled Compounds and RadiopharmaceuticalsVolume 48, Issue 4 p. 285-294 Research Article An improved bidentate complex of iridium as a catalyst for hydrogen isotope exchange John M. Herbert, Corresponding Author John M. Herbert john.herbert@sanofi-synthelabo.com Isotope Chemistry and Metabolite Synthesis Department, Sanofi-aventis, Willowburn Ave., Alnwick, Northumberland NE66 2JH, UKIsotope Chemistry and Metabolite Synthesis Department, Sanofi-aventis, Willowburn Ave., Alnwick, Northumberland NE66 2JH, UKSearch for more papers by this authorAndrew D. Kohler, Andrew D. Kohler Isotope Chemistry and Metabolite Synthesis Department, Sanofi-aventis, Willowburn Ave., Alnwick, Northumberland NE66 2JH, UKSearch for more papers by this authorAlan H. McNeill, Alan H. McNeill Isotope Chemistry and Metabolite Synthesis Department, Sanofi-aventis, Willowburn Ave., Alnwick, Northumberland NE66 2JH, UKSearch for more papers by this author John M. Herbert, Corresponding Author John M. Herbert john.herbert@sanofi-synthelabo.com Isotope Chemistry and Metabolite Synthesis Department, Sanofi-aventis, Willowburn Ave., Alnwick, Northumberland NE66 2JH, UKIsotope Chemistry and Metabolite Synthesis Department, Sanofi-aventis, Willowburn Ave., Alnwick, Northumberland NE66 2JH, UKSearch for more papers by this authorAndrew D. Kohler, Andrew D. Kohler Isotope Chemistry and Metabolite Synthesis Department, Sanofi-aventis, Willowburn Ave., Alnwick, Northumberland NE66 2JH, UKSearch for more papers by this authorAlan H. McNeill, Alan H. McNeill Isotope Chemistry and Metabolite Synthesis Department, Sanofi-aventis, Willowburn Ave., Alnwick, Northumberland NE66 2JH, UKSearch for more papers by this author First published: 08 February 2005 https://doi.org/10.1002/jlcr.921Citations: 18AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Iridium(I) complexes 1, containing bidentate phosphines, and 3, with arsine ligands, are generated in situ. These species mediate hydrogen isotope exchange in a variety of aromatic substrates including benzyl ketones. Although the catalytic activities of complexes 1 and 3 are generally unexceptional, a logical step leads to the use of [ethylene-1,2-bis(diphenylarsine)](cyclooctadiene)iridium(I) tetrafluoroborate (5), which is an efficient catalyst for both aryl and benzyl ketones, and mediates exchange to a substantial extent in other substrates also. Copyright © 2005 John Wiley & Sons, Ltd. Citing Literature Volume48, Issue430 March 2005Pages 285-294 RelatedInformation