Portal de Periódicos da CAPES

Disialoganglioside GD2 as a therapeutic target for human diseases

2015; Taylor & Francis; Volume: 19; Issue: 3 Linguagem: Inglês

10.1517/14728222.2014.986459

1744-7631

Maya Suzuki, Nai‐Kong V. Cheung,

Cell death mechanisms and regulation

Introduction: Ganglioside GD2 is found in vertebrates and invertebrates, overexpressed among pediatric and adult solid tumors, including neuroblastoma, glioma, retinoblastoma, Ewing's family of tumors, rhabdomyosarcoma, osteosarcoma, leiomyosarcoma, liposarcoma, fibrosarcoma, small cell lung cancer and melanoma. It is also found on stem cells, neurons, some nerve fibers and basal layer of the skin.