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Further investigation on the high-conductance ion channel of the inner membrane of mitochondria

1989; Springer Science+Business Media; Volume: 21; Issue: 4 Linguagem: Inglês

10.1007/bf00762520

1573-6881

Maria Catia Sorgato, Óscar Morán, Vito De Pinto, Bernhard U. Keller, Walter Stuehmer,

Ion channel regulation and function

By use of the patch-clamp technique, the inner membrane of mouse liver and heart mitochondria is shown to contain a highly conductive (around 100 pS in symmetrical 150 mM KCl) and voltage-dependent ion channel. This channel closely resembles that previously found in cuprizone-treated mouse liver inner mitochondrial membrane. The paper discusses the electrical properties of the channel and its possible physiological function. The reconstitution in giant liposomes of a partially purified ox heart inner membrane fraction containing the channel and the use of various inhibitors are also presented.