Effect of hairpin loop structure on reactivity, sequence preference and adduct orientation of a DNA-interactive pyrrolo[2,1-c][1,4]benzodiazepine (PBD) antitumour agent
2015; Royal Society of Chemistry; Volume: 13; Issue: 13 Linguagem: Inglês
10.1039/c4ob02405b
ISSN1477-0539
AutoresDavid E. Thurston, Higia Vassoler, Paul J. Jackson, C. James, Khondaker Miraz Rahman,
Tópico(s)HIV/AIDS drug development and treatment
ResumoPyrrolobenzodiazepine (PBD) monomer GWL-78 reacts faster with DNA hairpins containing a hexaethylene glycol (HEG) loop compared to hairpins containing a TTT loop due to the greater structural flexibility of the HEG.
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