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A Unimolecular G-Quadruplex that Functions as a Synthetic Transmembrane Na + Transporter

2005; American Chemical Society; Volume: 128; Issue: 1 Linguagem: Inglês

10.1021/ja056888e

1943-2984

Mark S. Kaucher, William A. Harrell, Jeffery T. Davis,

RNA Interference and Gene Delivery

We describe the covalent post-modification of a hydrogen-bonded assembly with the subsequent formation of a potent transmembrane Na+ ion transporter. Olefin metathesis is used to cross-link all 16 guanosine subunits in a lipophilic G-quadruplex. The resulting unimolecular G-quadruplex folds in the environment of a phospholipid membrane and functions as a Na+ ion transporter as judged by fluorescence and 23Na NMR transport assays.