Rhodium-Catalyzed Asymmetric 1,4-Addition of Arylboronic Acids to Coumarins: Asymmetric Synthesis of ( R )-Tolterodine
2005; American Chemical Society; Volume: 7; Issue: 11 Linguagem: Inglês
10.1021/ol0507367
ISSN1523-7060
AutoresGang Chen, Norihito Tokunaga, Tamio Hayashi,
Tópico(s)Asymmetric Hydrogenation and Catalysis
ResumoRhodium-catalyzed asymmetric 1,4-addition of arylboronic acids to coumarins proceeded with high enantioselectivity in the presence of a rhodium catalyst (3 mol %) generated from Rh(acac)(C2H4)2 and (R)-Segphos to give the corresponding (R)-4-arylchroman-2-ones in over 99% ee. This asymmetric reaction was applied to the synthesis of (R)-tolterodine.
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