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Use of cohort data to estimate national prevalence of transmitted drug resistance to antiretroviral drugs in Spain (2007–2012)

2014; Elsevier BV; Volume: 21; Issue: 1 Linguagem: Inglês

10.1016/j.cmi.2014.08.007

1469-0691

Susana Monge, María José Díez, M Álvarez, Vicente Guillot, José Antonio Iribarren, Rosario Palacios, R. Delgado, Ángeles Jaén, José Ramón Blanco, Peré Domingo, Joaquín Portilla, Maria Jesús Pérez‐Elías, Felipe García,

HIV/AIDS Research and Interventions

Prevalence of transmitted drug resistance (pTDR) to antiretroviral drugs in Spain (2007–2012) was estimated using the CoRIS cohort, adjusting its territorial distribution and transmission route to the reference population from the Spanish Information System on New human immunodeficiency virus diagnoses. A total of 2702 patients from ten autonomous communities and with naive FASTA sequence within 6 months of human immunodeficiency virus diagnosis were selected. Weighted pTDR, estimated using the inverse probability of selection in the sample by autonomous communities and transmission group, was 8.12% (95% CI 6.44–9.80), not significantly different from unweighted pTDR. We illustrate how proportional weighting can maximize representativeness of cohort-based data, and its value to monitor pTDR at country level.