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Evaluation of Glutathione S-Transferase GSTM1 and GSTT1 Deletion Polymorphisms on Type-2 Diabetes Mellitus Risk

2013; Public Library of Science; Volume: 8; Issue: 10 Linguagem: Inglês

10.1371/journal.pone.0076262

1932-6203

Denise da Silva Pinheiro, César Ramos Rocha-Filho, Cláudia Aparecida Mundim, Paulo de Marco Júnior, Cirano José Ulhôa, Ângela Adamski da Silva Reis, Paulo César Ghedini,

Agriculture and Biological Studies

Due to the activity of GSTs in the detoxification of oxidative stress products, deletion polymorphisms of GSTM1 and GSTT1 may contribute to susceptibility to T2DM, since B-cells express very low levels of antioxidant enzymes. Recently, some studies have shown an association between GSTM1-null/GSTT1-null genotypes and an increased susceptibility to T2DM. A relationship between these polymorphisms and changes in the clinical parameters of diabetic patients has also been investigated. However, the results diverge considerably among the studies. Thus, this case-control study was designed to contribute to existing knowledge, as there are no studies on this issue performed in the Brazilian population.