Portal de Periódicos da CAPES

Hepatotoxicity Associated with Supplements Containing Chinese Green Tea ( Camellia sinensis )

2006; American College of Physicians; Volume: 144; Issue: 1 Linguagem: Inglês

10.7326/0003-4819-144-1-200601030-00020

1539-3704

Herbert L. Bonkovsky,

Nephrotoxicity and Medicinal Plants

Letters3 January 2006Hepatotoxicity Associated with Supplements Containing Chinese Green Tea (Camellia sinensis)Herbert L. Bonkovsky, MDHerbert L. Bonkovsky, MDFrom the University of Connecticut Health Center, Farmington, CT 06030.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-144-1-200601030-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Background: Recent reports have identified an association between hepatotoxicity and health supplements containing green tea extract (Camellia sinensis).Objective: To present a new case study involving a patient who exhibited a positive response to a rechallenge and to summarize previous reports of C. sinensis-associated hepatotoxicity.Methods and Findings: A 37-year-old Hispanic woman was evaluated for a 10-day history of diffuse abdominal pain, nausea, and jaundice. She had been using a weight-loss supplement called The Right Approach Complex (Pharmanex, Provo, Utah) for 4 months. She was afebrile. Her serum aspartate aminotransferase (AST) level was 1783 U/L (reference range, ...References1. Stevens T, Qadri A, Zein NN. Two patients with acute liver injury associated with use of the herbal weight-loss supplement Hydroxycut [Letter]. Ann Intern Med. 2005;142:477-8. [PMID: 15767636] LinkGoogle Scholar2. Porcel JM, Bielsa S, Madronero AB. Hepatotoxicity associated with green tea extracts [electronic letter]. Accessed at www.annals.org on 3 June 2005. Google Scholar3. Pedros C, Cereza G, Garcia N, Laporte JR. [Liver toxicity of Camellia sinensis dried etanolic extract] [Letter]. Med Clin (Barc). 2003;121:598-9. [PMID: 14622530] MedlineGoogle Scholar4. Garcia-Moran S, Saez-Royuela F, Gento E, Lopez Morante A, Arias L. [Acute hepatitis associated with Camellia thea and Orthosiphon stamineus ingestion] [Letter]. Gastroenterol Hepatol. 2004;27:559-60. [PMID: 15544745] CrossrefMedlineGoogle Scholar5. Thiolet C, Mennecier D, Bredin C, Moulin O, Rimlinger H, Nizou C, et al. [Acute cytolysis induced by Chinese tea] [Letter]. Gastroenterol Clin Biol. 2002;26:939-40. [PMID: 12434106] MedlineGoogle Scholar6. Vial T, Bernard G, Lewden B, Dumortier J, Descotes J. [Acute hepatitis due to Exolise, a Camellia sinensis-derived drug] [Letter]. Gastroenterol Clin Biol. 2003;27:1166-7. [PMID: 14770123] MedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Herbert L. Bonkovsky, MDAffiliations: From the University of Connecticut Health Center, Farmington, CT 06030.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoTwo Patients with Acute Liver Injury Associated with Use of the Herbal Weight-Loss Supplement Hydroxycut Tyler Stevens , Asif Qadri , and Nizar N. Zein Correction: Hepatotoxicity Associated with Supplements Containing Chinese Green Tea (Camellia sinensis) Metrics Cited byThe Threat of Weight-Loss Over the Counter Supplements: A Case of Camellia Sinensis Autoimmune HepatitisAASLD practice guidance on drug, herbal, and dietary supplement–induced liver injuryEffect of epigallocatechin gallate on the fermentative and physicochemical properties of fermented milkA novel extraction method enhanced the osteogenic and anti-osteoporosis effect of tea extract without any hepatotoxicity in ovariectomized ratsPotential Application of Tea Polyphenols to the Prevention of COVID-19 Infection: Based on the Gut-Lung AxisLiver biomarkers in adults: Evaluation of associations with reported green tea consumption and use of green tea supplements in U.S. NHANESPrenatal EGCG exposure-induced heart mass reduction in adult male mice and underlying mechanismsPolyphenols: A Comprehensive Review of their Nutritional PropertiesHLA‐B*35:01 and Green Tea–Induced Liver InjuryThe link among microbiota, epigenetics, and disease developmentEpigallocatechin Gallate in Relapsing-Remitting Multiple SclerosisACG Clinical Guideline: Diagnosis and Management of Idiosyncratic Drug-Induced Liver InjuryLiver Injury Caused by Green Tea Extract in PD-1 –/– Mice: An Impaired Immune Tolerance Model for Idiosyncratic Drug-Induced Liver InjuryNutraceuticals Supporting Cognitive Function in Mild Cognitive ImpairmentTea CatechinsNutrition, supplementation and weight reduction in combat sports: a reviewInfluence of green tea consumption on endoxifen steady-state concentration in breast cancer patients treated with tamoxifenManaging obesity through natural polyphenols: A reviewFlavonoids Activation of the Transcription Factor Nrf2 as a Hypothesis Approach for the Prevention and Modulation of SARS-CoV-2 Infection SeverityIs a higher ingestion of phenolic compounds the best dietary strategy? A scientific opinion on the deleterious effects of polyphenols in vivoActualité dans l’hépatotoxicité des médicaments et autres xénobiotiques. Le rôle des compléments alimentairesPublic Knowledge, Attitude, and Practice on Herbal Remedies Used During Pregnancy and Lactation in West Bank PalestineIcariside II inhibits tumorigenesis via inhibiting AKT/Cyclin E/ CDK 2 pathway and activating mitochondria-dependent pathwayDeterminación del riesgo de daño hepático relacionado a los medicamentos AINEs en pacientes con Chikun-Gunya y Zika.Tea CatechinsTea CatechinsTea CatechinsUnited States Pharmacopeia (USP) comprehensive review of the hepatotoxicity of green tea extractsAlleviation of Multidrug Resistance by Flavonoid and Non-Flavonoid Compounds in Breast, Lung, Colorectal and Prostate CancerAssuring that your cup of tea is risk-freeBiological and toxicological evaluation of Rhus trilobata Nutt. (Anacardiaceae) used traditionally in mexico against cancerDrug-Induced Liver Injury — Types and PhenotypesStudies on the Prevention of Cancer and Cardiometabolic Diseases by Tea: Issues on Mechanisms, Effective Doses, and ToxicitiesA Behavioral Confirmation and Reduction of the Natural versus Synthetic Drug BiasA Review of the Role of Green Tea (Camellia sinensis) in Antiphotoaging, Stress Resistance, Neuroprotection, and AutophagyEffects of medium-term green tea extract supplementation combined with CrossFit workout on blood antioxidant status and serum brain-derived neurotrophic factor in young men: a pilot studyRisks associated with fat burners: A toxicological perspectiveParadoxical cardiotoxicity of intraperitoneally-injected epigallocatechin gallate preparation in diabetic miceDifferential Impact of Flavonoids on Redox Modulation, Bioenergetics, and Cell Signaling in Normal and Tumor Cells: A Comprehensive ReviewEpigallocatechin gallate: a reviewBotanicals and HepatotoxicityDrug-Induced Liver InjuryOrganic solute carrier 22 (SLC22) family: Potential for interactions with food, herbal/dietary supplements, endogenous compounds, and drugsInteractions Between Herbs and Anti-infective MedicationsAnticancer Potential of Dietary PolyphenolsPolyphenols as Supplements in Foods and Beverages: Recent Discoveries and Health Benefits, an UpdateBeneficial effects of polyphenols on chronic diseases and ageingDrug-Induced Liver InjuryMechanistic evaluation of phytochemicals in breast cancer remedy: current understanding and future perspectivesSafety assessment of the dietary supplement OxyELITE™ Pro (New Formula) in inbred and outbred mouse strainsLiver toxicity related to herbs and dietary supplements: Online table of case reports. Part 2 of 5 seriesDietary flavonoids and modulation of natural killer cells: implications in malignant and viral diseasesDietary exposure to honeybush (Cyclopia) polyphenol-enriched extracts altered redox status and expression of oxidative stress and antioxidant defense-related genes in rat liverBioactive nutrients - Time for tolerable upper intake levels to address safetyGreen Tea Consumption and the Risk of Liver Cancer: A Meta-AnalysisHerbal and Dietary Supplement–Induced Liver InjuryNephro-toxic effects of intraperitoneally injected EGCG in diabetic mice: involvement of oxidative stress, inflammation and apoptosisLiver injury from herbal and dietary supplementsHerbal HepatotoxicityDevelopment of phenolic compounds encapsulation techniques as a major challenge for food industry and for health and nutrition fieldsProtective effect of epigallocatechin gallate against N-nitrosodiethylamine (NDEA) induced toxicity in ratsErratum to: Severe Acute Hepatocellular Injury Attributed to OxyELITE Pro: A Case SeriesDaño hepático debido al uso de suplementos nutricionales y de herbolario: revisión de componentes individualesThe Influence of Safety, Efficacy, and Medical Condition Severity on Natural versus Synthetic Drug PreferenceRandomized, placebo-controlled trial evaluating the safety of one-year administration of green tea catechinsSevere Acute Hepatocellular Injury Attributed to OxyELITE Pro: A Case SeriesToxic hepatitis due to a food supplement: “Natural” is no synonym for “harmless”Traditional Chinese Medicine (TCM) and Herbal Hepatotoxicity: RUCAM and the Role of Novel Diagnostic Biomarkers Such as MicroRNAsSafety and anti-hyperglycemic efficacy of various tea types in miceRisk of Liver Injury Associated with Green Tea Extract in SLIMQUICK® Weight Loss Products: Results from the DILIN Prospective StudyHerbal Hepatotoxicity: Clinical Characteristics and Listing CompilationLiver injury due to herbal and dietary supplements: A review of individual ingredientsHepatotoxicity by Dietary Supplements: A Tabular Listing and Clinical CharacteristicsScientific and Regulatory Perspectives in Herbal and Dietary Supplement Associated Hepatotoxicity in the United StatesDrug-Induced Liver Injury: Pattern Recognition and Future DirectionsHerbal Medicines: Boon or Bane for the Human Liver?ClusiaceaeTheaceaeAcute and Subchronic Oral Toxicity Evaluation of Aqueous Root Extract of Dicoma anomala Sond. in Wistar RatsComparative In Vitro Cytotoxicity of 20 Potential Food Ingredients in Canine Liver, Kidney, Bone Marrow-Derived Mesenchymal Stem Cells, and Enterocyte-like CellsShort-Term and Sub-Chronic Dietary Exposure to Aspalathin-Enriched Green Rooibos (Aspalathus linearis) Extract Affects Rat Liver Function and Antioxidant StatusTea and Its Consumption: Benefits and RisksLiver Failure after Hydroxycut™ Use in a Patient with Undiagnosed Hereditary CoproporphyriaCLINICAL EFFICACY TRIALS WITH NATURAL PRODUCTS AND HERBAL MEDICINESConcentrated green tea supplement: Biological activity and molecular mechanismsHerbal Products and the Liver: A Review of Adverse Effects and MechanismsSensitivity to hepatotoxicity due to epigallocatechin gallate is affected by genetic background in diversity outbred miceOver the Counter Nutritional Supplements: Implications for Critically Ill PatientsTraditional Chinese Medicine and herbal hepatotoxicity: a tabular compilation of reported casesImplications of Green Tea and Its Constituents in the Prevention of Cancer via the Modulation of Cell Signalling PathwayNitric oxide and reactive species are modulated in the polyphenol-induced ductus arteriosus constriction in pregnant sheepReview of the regulations for clinical research in herbal medicines in USAAnti-inflammatory action of γ-irradiated genistein in murine peritoneal macrophageGreen tea extract and the risk of drug-induced liver injuryComplementary and Alternative MedicineSafety and Chemopreventive Effect of Polyphenon E in Preventing Early and Metastatic Progression of Prostate Cancer in TRAMP MiceHerbal hepatotoxicity: Analysis of cases with initially reported positive re-exposure testsAnticancer effects and molecular mechanisms of epigallocatechin-3-gallateOver-the-Counter Nutritional Supplements: Implications for Critically Ill PatientsPolyphenols as Supplements in Foods and BeveragesBioefficacy of tea catechins encapsulated in casein micelles tested on a normal mouse cell line (4D/WT) and its cancerous counterpart (D/v-src) before and after in vitro digestionA Review of Hepatoprotective Plants Used in Saudi Traditional MedicineModulators of amyloid protein aggregation and toxicity: EGCG and CLR01Liver Injury Induced by Herbal Complementary and Alternative MedicineEffect of green tea and its polyphenols on mouse liverTea: A new perspective on health benefitsCatechins in Dietary Supplements and HepatotoxicityKrebspräventionToxicity of Green Tea PolyphenolsCancer Chemoprevention by Polyphenols and Their Potential Application as NanomedicineToxicology and Safety of FlavonoidsHerbal hepatotoxicity: a tabular compilation of reported casesEvaluation of oral subchronic toxicity of Pu-erh green tea (camellia sinensis var. assamica) extract in Sprague Dawley ratsAcute Liver Injury due to Flavocoxid (Limbrel), a Medical Food for Osteoarthritis A Case SeriesNaga Chalasani, MD, Raj Vuppalanchi, MD, Victor Navarro, MD, Robert Fontana, MD, Herbert Bonkovsky, MD, Huiman Barnhart, PhD, David E. Kleiner, MD, and Jay H. Hoofnagle, MD, on behalf of the Drug-Induced Liver Injury NetworkHepatotoxicity of Herbal PreparationsHealth-promoting effects of green teaEGCG downregulates IL-1RI expression and suppresses IL-1-induced tumorigenic factors in human pancreatic adenocarcinoma cellsContinuous reporting of new cases in Spain supports the relationship between Herbalife® products and liver injuryThe treatment of bladder cancer in a mouse model by epigallocatechin-3-gallate-gold nanoparticlesEpigallocatechin-3-gallate (EGCG) for Clinical Trials: More Pitfalls than Promises?Weight control and prevention of metabolic syndrome by green teaCancer prevention by tea: Evidence from laboratory studiesMechanistic issues concerning cancer prevention by tea catechinsHealth Benefits of TeaAcute and subchronic oral toxicities of Pu-erh black tea extract in Sprague–Dawley ratsInteractions Between Herbs and Antiinfective MedicationsTreatments used in complementary and alternative medicineDrug Induced Liver Disease: Mechanisms and DiagnosisThe antioxidant and pro-oxidant activities of green tea polyphenols: A role in cancer preventionHepatotoxicity Due to Hydroxycut: A Case SeriesMonographs of Herbal PrinciplesSteep Your Genes in Health: Drink TeaCancer Prevention by Catechins, Flavonols, and ProcyanidinsHepatotoxicity of high oral dose (−)-epigallocatechin-3-gallate in miceAcute liver injury induced by weight-loss herbal supplementsPolyphenols in the prevention and treatment of sepsis syndromes: Rationale and pre-clinical evidenceHepatotoxic herbs: Will injury mechanisms guide treatment strategies?Safety assessment of heat-sterilized green tea catechin preparation: A 6-month repeat-dose study in ratsExposure and toxicity of green tea polyphenols in fasted and non-fasted dogsCancer prevention by tea: animal studies, molecular mechanisms and human relevanceDrug-Induced Liver Disease and Drug Use Considerations in Liver DiseaseEpigallocatechin-gallate modulates chemotherapy-induced apoptosis in human cholangiocarcinoma cellsHepatitis Caused by Lotus-f3?Human drug hepatotoxicity: a contemporary clinical perspectiveHepatotoxicity from green tea: a review of the literature and two unpublished casesSevere Hepatotoxicity Due to Hydroxycut: A Case ReportAn in vitro investigation of herbs traditionally used for kidney and urinary system disorders: Potential therapeutic and toxic effectsSevere hepatotoxicity following ingestion of Herbalife® nutritional supplements contaminated with Bacillus subtilisCauses, Clinical Features, and Outcomes From a Prospective Study of Drug-Induced Liver Injury in the United StatesSpanish reports of hepatotoxicity associated with Herbalife® productsHepatotoxicidad inducida por el uso de hierbas y medicamentos para perder pesoBioavailability issues in studying the health effects of plant polyphenolic compoundsFactores de riesgo y mecanismos de toxicidad hep?ticaHepatotoxic slimming aids and other herbal hepatotoxinsIdiosyncratic drug hepatotoxicity: a 2008 updateSafety of Green Tea ExtractsHydroxycut hepatotoxicity: A case series and review of liver toxicity from herbal weight loss supplementsHerbal does not mean innocuous: Ten cases of severe hepatotoxicity associated with dietary supplements from Herbalife® productsAcute Liver Injury Associated With the Herbal Supplement Hydroxycut in a Soldier Deployed to IraqSerious adverse liver reactions associated with herbal weight-loss supplementsMechanisms and Effects of Green Tea on Cardiovascular HealthDrug-induced liver disease in 2006Herbal medicine in the treatment of liver diseasesPossible Controversy over Dietary Polyphenols: Benefits vs RisksAcute liver failure induced by green tea extracts: Case report and review of the literatureEffects of Repeated Green Tea Catechin Administration on Human Cytochrome P450 ActivityAn evidence-based systematic review of herb and supplement interactions by the Natural Standard Research CollaborationHepatotoxicity due to extracts of Chinese green tea (Camellia sinensis): A growing concernHerbal hepatotoxicity – replyCorrection: Hepatotoxicity Associated with Supplements Containing Chinese Green Tea (Camellia sinensis) 3 January 2006Volume 144, Issue 1Page: 68-71KeywordsAbdominal painAlanine aminotransferaseBilirubinInflammationLiverNauseaPhosphatasesSerum albuminSerum glutamic oxaloacetic transaminaseTea ePublished: 3 January 2006 Issue Published: 3 January 2006 Copyright & PermissionsCopyright © 2006 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...