Produção Nacional
The Antidepressant-like Effect of Hyperbrasilol B, A Natural Dimeric Phloroglucinol Derivative is Prevented by Veratrine, a Sensitive-Voltage Na+ Channel Opener
2014; Volume: 4; Issue: 11 Linguagem: Inglês
10.9734/ejmp/2014/7702
ISSN2231-0894
AutoresFernanda Bossemeyer Centurião, Satchie Sakamoto, Ana Cristina Stein, Liz Girardi Müller, Pietro Maria Chagas, Gilsane Lino von Poser, Cristina W. Nogueira, Stela Maris Kuze Rates,
Tópico(s)Synthesis and Properties of Aromatic Compounds
ResumoAims: South Brazilian Hypericum species are a source of dimeric structures, constituted of filicinic acid and phloroglucinol moieties, which present antidepressant-like effects mediated by monoaminergic neurotransmission in rodents.Here, we show that hyperbrasilol B, a phloroglucinol derivative from Hypericum caprifoliatum, presents
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