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BIBTEX RIS

H‐Y antigen in 46,XY pure testicular dysgenesis

1979; Wiley; Volume: 3; Issue: 2 Linguagem: Inglês

10.1002/ajmg.1320030206

ISSN

1096-8628

Autores

H. R. S. Nazareth, Carlos Alberto Moreira‐Filho, A. J. B. Cunha, João Paulo Botelho Vieira‐Filho, A. M. J. Lengyel, Marta Cunha Lima, John M. Optiz,

Tópico(s)

Testicular diseases and treatments

Resumo

Abstract Clinical, cytogenetic, pathologic and histocompatibility‐Y (H‐Y) antigen studies were performed on a phenotypic female with primary amenorrhea and streak gonads. Pathological examination of tissues removed at total hysterectomy and bilateral salpingo‐gonadectomy showed gonadoblastoma and dysgerminoma of left streak. A single F‐body (Y chromosome) was found in buccal smears. Analysis of blood cells and tumor fibroblasts showed a 46, XY chromosome constitution (Q‐banding). The data were consistent with a diagnosis of 46, XY pure testicular dysgenesis. Positive results for H‐Y antigen were found in this case.

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