Enhancement of ethanol-induced sedation and hypothermia by centrally administered neurotensin, β-endorphin and bombesin
1981; Elsevier BV; Volume: 20; Issue: 3 Linguagem: Inglês
10.1016/0028-3908(81)90139-8
ISSN1873-7064
AutoresDaniel Luttinger, Charles B. Nemeroff, George Mason, Gerald D. Frye, George R. Breese, Arthur J. Prange,
Tópico(s)Pain Mechanisms and Treatments
ResumoIntracisternal administration of three endogenous neuropeptides (neurotensin, β-endorphin, or bombesin) potentiated the duration of sedation induced by a fixed dose of ethanol (5.2 g/kg) in mice. The minimally effective dose of each peptide that enhanced ethanol-induced sedation was: neurotensin, 0.18 nmoles; β-endorphin, 1.79 nmoles; and bombesin, 0.06 nmoles. The enhancement of ethanol-induced sedation was correlated with the potentiation of ethanol-induced hypothermia for all three peptides. None of the neuropeptides studied significantly altered blood or brain ethanol concentrations, suggesting that the observed effects were not due to differences in ethanol metabolism.
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