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Lipase/Aluminum‐Catalyzed Dynamic Kinetic Resolution of Secondary Alcohols

2006; Wiley; Volume: 45; Issue: 39 Linguagem: Inglês

10.1002/anie.200600379

1521-3773

Albrecht Berkessel, M. Luisa Sebastian‐Ibarz, Thomas N. Müller,

Analytical Chemistry and Chromatography

Racemization wanted: The dynamic kinetic resolution of secondary alcohols can be achieved by a simple and readily available catalyst system. Substrate racemization is effected at room temperature by a combination of (racemic) 1,1′-bi-2-naphthol (binol) or 2,2′-biphenol with AlMe3, and a lipase performs enantiospecific acylation (see scheme). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z600379_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.