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Natural and synthetic G-quadruplex interactive berberine derivatives

2006; Elsevier BV; Volume: 16; Issue: 6 Linguagem: Inglês

10.1016/j.bmcl.2005.12.001

1464-3405

Marco Franceschin, Luigi Rossetti, A D'Ambrosio, Stefano Schirripa, Armandodoriano Bianco, Giancarlo Ortaggi, Maria Savino, Christoph Schultes, Stephen Neidle,

RNA Interference and Gene Delivery

The interaction of the natural alkaloid berberine with various G-quadruplex DNA structures and its ability to inhibit telomerase have been examined and compared with those of a synthetic piperidino derivative and the related compound coralyne. The results show that these molecules have selectivity for G-quadruplex compared to duplex DNA, and that their aromatic moieties play a dominant role in quadruplex binding.