GATA-3 Promotes Maturation, IFN-γ Production, and Liver-Specific Homing of NK Cells
2003; Cell Press; Volume: 19; Issue: 5 Linguagem: Inglês
10.1016/s1074-7613(03)00294-2
ISSN1097-4180
AutoresSandrine I. Samson, Odile Richard, Manuela Tavian, Thomas Ranson, Christian A. J. Vosshenrich, Francesco Colucci, Jan Buer, Frank Grosveld, Isabelle Godin, James P. Di Santo,
Tópico(s)T-cell and B-cell Immunology
ResumoThe GATA-3 transcription factor has a determinant role in T cell specification and is an essential mediator of T helper 2-type polarized immune responses. While both committed NK precursors and mature NK cells express GATA-3, a role of this transcription factor in murine NK cell differentiation is not known. We found that NK cells, in contrast to T cells, can be generated in the absence of GATA-3. However, while GATA-3 antagonizes IFN-γ production in differentiating T cells, GATA-3-deficient NK cells paradoxically produced less IFN-γ compared to control NK cells and failed to provide early protection in vivo against infection with Listeria monocytogenes. Surprisingly, GATA-3 was essential for NK cell homing to the liver. Our results suggest that GATA-3 promotes NK cell maturation and acts in this lineage to specify distinct effector phenotypes.
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