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Artigo Acesso aberto Revisado por pares
BIBTEX RIS

Fluorous Synthesis of Disubstituted Pyrimidines

2003; American Chemical Society; Volume: 5; Issue: 7 Linguagem: Inglês

10.1021/ol027469e

ISSN

1523-7060

Autores

Wei Zhang,

Tópico(s)

Innovative Microfluidic and Catalytic Techniques Innovation

Resumo

[reaction: see text] The fluorous synthesis of disubstituted pyrimidines is carried out by attaching 2,4-dichloro-6-methylpyrimidine with 1H,1H,2H,2H-perfluorodecanethiol. The tagged substrate is substituted with 3-(trifluoromethyl)pyrazole followed by thioether oxidation and tag displacement with amines or thiols. The fluorous chain serves as a phase tag for intermediate and product purification over FluoroFlash SPE cartridges.

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