Synthesis of Cyclic Bis(3′‐5′)‐2′‐deoxyguanylic/guanylic Acid ( c ‐dGpGp) and Its Biological Activities to Microbes
2007; Wiley; Volume: 2; Issue: 10 Linguagem: Inglês
10.1002/cmdc.200700072
ISSN1860-7187
AutoresErina Mano, Mamoru Hyodo, Yumi Sato, Yuka Ishihara, Michio Ohta, Yoshihiro Hayakawa,
Tópico(s)Probiotics and Fermented Foods
Resumoc-di-GMP is considered to play an important role in regulating exopolysaccharide production, biofilm formation, and other phenotypes in bacteria. These attractive biological properties of c-di-GMP prompted us to carry out a systematic study of the bioactivity of c-di-GMP-related compounds, including derivatives with modified nucleoside bases, carbohydrates, or internucleotide bonds. Synthesis of c-dGpGp and its biological activities is reported.
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