Synthesis, biochemical activity and behavioral effects of a series of 1,4,5,6-tetrahydropyrimidines as novel ligands for M1 receptors
1992; Elsevier BV; Volume: 2; Issue: 8 Linguagem: Inglês
10.1016/s0960-894x(00)80531-4
ISSN1464-3405
AutoresWilliam S. Messer, Philip G. Dunbar, Taikyun Rho, Sumudra Periyasamy, Dan O. Ngur, Brenda R. Ellerbrock, Mark Bohnett, Kevin Ryan, Graham J. Durant, Wayne Hoss,
Tópico(s)Nicotinic Acetylcholine Receptors Study
ResumoAbstract A series of novel tetrahydropyrimidines was synthesized and examined for M 1 muscarinic receptor activity. 1,4,5,6-Tetrahydro-5-methoxycarbonyl-pyrimidine hydrobromide ( 1a ; CDD-0034-C) displayed a high affinity for muscarinic receptors in rat brain and stimulated PI metabolism in rat hippocampus. Compound 1a ameliorated memory deficits associated with lesions of the septohippocampal cholinergic system in rats.
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