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Nasal Inoculation of the Commensal Neisseria lactamica Inhibits Carriage of Neisseria meningitidis by Young Adults: A Controlled Human Infection Study

2015; Oxford University Press; Volume: 60; Issue: 10 Linguagem: Inglês

10.1093/cid/civ098

1537-6591

Alice M. Deasy, Ed Guccione, Adam P. Dale, Nick Andrews, Cariad Evans, Julia S. Bennett, Holly B. Bratcher, Martin Maiden, Andrew Gorringe, Robert C. Read,

Sinusitis and nasal conditions

Background. Herd protection by meningococcal vaccines is conferred by population-level reduction of meningococcal nasopharyngeal colonization. Given the inverse epidemiological association between colonization by commensal Neisseria lactamica and meningococcal disease, we investigated whether controlled infection of human volunteers with N. lactamica prevents colonization by Neisseria meningitidis.