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Multicomponent Biginelli's synthesis of 3,4-dihydropyrimidin-2(1H)-ones promoted by SnCl2.2H2O

2004; Brazilian Chemical Society; Volume: 15; Issue: 2 Linguagem: Inglês

10.1590/s0103-50532004000200002

ISSN

1678-4790

Autores

Dennis Russowsky, Fabrício Abella Lopes, Verónica Silva, Karen Canto, Marcelo G. Montes D’Oca, Marla N. Godoi,

Tópico(s)

Microwave-Assisted Synthesis and Applications

Resumo

The ability of SnCl2.2H2O as catalyst to promote the Biginelli three-component condensation reaction from a diversity of aromatic aldehydes, ethyl acetoacetate and urea or thiourea is described. The reaction was carried out in acetonitrile or ethanol as solvents in neutral media and represents an improvement of the classical Biginelli protocol and an advantage in comparison with FeCl3.6H2O, NiCl2.6H2O and CoCl2.6H2O which were used with HCl as co-catalyst. The synthesis of 3,4-dihydropyrimidinones was achieved in good to excelent yields.

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